Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.

Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while oth...

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Autores principales:	Jun Wang, Zhong Zhao, Emi Lin, Wei Zhao, Xianjuan Qian, Daniel Freire, Amanda E Bilski, Alice Cheng, Prashant Vempati, Lap Ho, Kenjiro Ono, Masahito Yamada, Giulio M Pasinetti
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08eba08cf451466ba8c7eaca10899b6a
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spelling	oai:doaj.org-article:08eba08cf451466ba8c7eaca10899b6a2021-11-18T07:42:47ZUnintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.1932-620310.1371/journal.pone.0065232https://doaj.org/article/08eba08cf451466ba8c7eaca10899b6a2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23762322/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while others might exacerbate, the pathogenesis of AD. We screened 1,600 FDA approved drugs for β-amyloid (Aβ)-modifying activity and identified drugs that can potentially influence amyloid precursor protein processing. In this study, we focused on cardiovascular drugs and demonstrated that some hypertensive medication can differentially modulate Aβ, both in vitro and in vivo. Our study suggests that some commonly prescribed drugs might exert unintended effects and modulate AD and provides the basis for continuing investigation of the role of individual drugs on a case-by-case basis. This line of investigation will lead to the identification of common medications that are potentially beneficial or detrimental to AD as a reference for physicians to consider when prescribing the most appropriate drugs for their patients, particularly for treating chronic disorders among the growing geriatric population.Jun WangZhong ZhaoEmi LinWei ZhaoXianjuan QianDaniel FreireAmanda E BilskiAlice ChengPrashant VempatiLap HoKenjiro OnoMasahito YamadaGiulio M PasinettiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 6, p e65232 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Wang Zhong Zhao Emi Lin Wei Zhao Xianjuan Qian Daniel Freire Amanda E Bilski Alice Cheng Prashant Vempati Lap Ho Kenjiro Ono Masahito Yamada Giulio M Pasinetti Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.
description	Alzheimer's disease (AD) is rapidly becoming one of the leading causes of disability and mortality in the elderly. As life-expectancy increases, an increasing number of people will rely on modern medicines to treat age-associated disorders. Among these medications, some might benefit, while others might exacerbate, the pathogenesis of AD. We screened 1,600 FDA approved drugs for β-amyloid (Aβ)-modifying activity and identified drugs that can potentially influence amyloid precursor protein processing. In this study, we focused on cardiovascular drugs and demonstrated that some hypertensive medication can differentially modulate Aβ, both in vitro and in vivo. Our study suggests that some commonly prescribed drugs might exert unintended effects and modulate AD and provides the basis for continuing investigation of the role of individual drugs on a case-by-case basis. This line of investigation will lead to the identification of common medications that are potentially beneficial or detrimental to AD as a reference for physicians to consider when prescribing the most appropriate drugs for their patients, particularly for treating chronic disorders among the growing geriatric population.
format	article
author	Jun Wang Zhong Zhao Emi Lin Wei Zhao Xianjuan Qian Daniel Freire Amanda E Bilski Alice Cheng Prashant Vempati Lap Ho Kenjiro Ono Masahito Yamada Giulio M Pasinetti
author_facet	Jun Wang Zhong Zhao Emi Lin Wei Zhao Xianjuan Qian Daniel Freire Amanda E Bilski Alice Cheng Prashant Vempati Lap Ho Kenjiro Ono Masahito Yamada Giulio M Pasinetti
author_sort	Jun Wang
title	Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.
title_short	Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.
title_full	Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.
title_fullStr	Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.
title_full_unstemmed	Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.
title_sort	unintended effects of cardiovascular drugs on the pathogenesis of alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/08eba08cf451466ba8c7eaca10899b6a
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Unintended effects of cardiovascular drugs on the pathogenesis of Alzheimer's disease.

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