MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.

MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation scree...

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Autores principales:	Georgina L Ryland, Jennifer L Bearfoot, Maria A Doyle, Samantha E Boyle, David Y H Choong, Simone M Rowley, Australian Ovarian Cancer Study Group, Richard W Tothill, Kylie L Gorringe, Ian G Campbell
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08ec2f5448d14f08b23bc274d1d87f50
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spelling	oai:doaj.org-article:08ec2f5448d14f08b23bc274d1d87f502021-11-18T07:21:22ZMicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.1932-620310.1371/journal.pone.0035805https://doaj.org/article/08ec2f5448d14f08b23bc274d1d87f502012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22536442/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation screening using massively-parallel sequencing of 712 miRNA genes in 86 ovarian cancer cases identified only 5 mutated miRNA genes, each in a different case. One mutation was located in the mature miRNA, and three mutations were predicted to alter the secondary structure of the miRNA transcript. Screening of the 3'-untranslated region of 18 candidate cancer genes identified one mutation in each of AKT2, EGFR, ERRB2 and CTNNB1. The functional effect of these mutations is unclear, as expression data available for AKT2 and EGFR showed no increase in gene transcript. Mutations in miRNA genes and 3'-untranslated regions are thus uncommon in ovarian cancer.Georgina L RylandJennifer L BearfootMaria A DoyleSamantha E BoyleDavid Y H ChoongSimone M RowleyAustralian Ovarian Cancer Study GroupRichard W TothillKylie L GorringeIan G CampbellPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e35805 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Georgina L Ryland Jennifer L Bearfoot Maria A Doyle Samantha E Boyle David Y H Choong Simone M Rowley Australian Ovarian Cancer Study Group Richard W Tothill Kylie L Gorringe Ian G Campbell MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
description	MicroRNAs are key regulators of gene expression and have been shown to have altered expression in a variety of cancer types, including epithelial ovarian cancer. MiRNA function is most often achieved through binding to the 3'-untranslated region of the target protein coding gene. Mutation screening using massively-parallel sequencing of 712 miRNA genes in 86 ovarian cancer cases identified only 5 mutated miRNA genes, each in a different case. One mutation was located in the mature miRNA, and three mutations were predicted to alter the secondary structure of the miRNA transcript. Screening of the 3'-untranslated region of 18 candidate cancer genes identified one mutation in each of AKT2, EGFR, ERRB2 and CTNNB1. The functional effect of these mutations is unclear, as expression data available for AKT2 and EGFR showed no increase in gene transcript. Mutations in miRNA genes and 3'-untranslated regions are thus uncommon in ovarian cancer.
format	article
author	Georgina L Ryland Jennifer L Bearfoot Maria A Doyle Samantha E Boyle David Y H Choong Simone M Rowley Australian Ovarian Cancer Study Group Richard W Tothill Kylie L Gorringe Ian G Campbell
author_facet	Georgina L Ryland Jennifer L Bearfoot Maria A Doyle Samantha E Boyle David Y H Choong Simone M Rowley Australian Ovarian Cancer Study Group Richard W Tothill Kylie L Gorringe Ian G Campbell
author_sort	Georgina L Ryland
title	MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
title_short	MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
title_full	MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
title_fullStr	MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
title_full_unstemmed	MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
title_sort	microrna genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/08ec2f5448d14f08b23bc274d1d87f50
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MicroRNA genes and their target 3'-untranslated regions are infrequently somatically mutated in ovarian cancers.

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