Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties

Linlin Zhong, Kyusik Yun Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea Abstract: Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functiona...

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Autores principales:	Zhong LL, Yun KS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/08f05c4f9a604de5a87680524dff8316
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spelling	oai:doaj.org-article:08f05c4f9a604de5a87680524dff83162021-12-02T02:10:44ZGraphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties1178-2013https://doaj.org/article/08f05c4f9a604de5a87680524dff83162015-08-01T00:00:00Zhttp://www.dovepress.com/graphene-oxide-modified-zno-particles-synthesis-characterization-and-a-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Linlin Zhong, Kyusik Yun Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea Abstract: Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functionalized by the organic solvent dimethylformamide, and the particles were covalently bonded to the surface of graphene oxide. The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy. Fourier transform infrared spectroscopy and X-ray diffraction were used to analyze the physical and chemical properties of the ZnO/graphene oxide composites that differed from those of the individual components. Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV. Excellent antibacterial activity of ZnO/graphene oxide composites was observed with a microdilution method in which minimum inhibitory concentrations of 6.25 µg/mL for Escherichia coli and Salmonella typhimurium, 12.5 µg/mL for Bacillus subtilis, and 25 µg/mL for Enterococcus faecalis. After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties. Keywords: graphene oxide, ZnO, characterization, antibacterial propertyZhong LLYun KSDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss Special Issue on diverse applications in Nano-Theranostics, Pp 79-92 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhong LL Yun KS Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties
description	Linlin Zhong, Kyusik Yun Department of Bionanotechnology, Gachon University, Gyeonggi-do, Republic of Korea Abstract: Nanosized ZnO particles with diameters of 15 nm were prepared with a solution precipitation method at low cost and high yield. The synthesis of the particles was functionalized by the organic solvent dimethylformamide, and the particles were covalently bonded to the surface of graphene oxide. The morphology of the graphene oxide sheets and ZnO particles was confirmed with field emission scanning electron microscopy and biological atomic force microscopy. Fourier transform infrared spectroscopy and X-ray diffraction were used to analyze the physical and chemical properties of the ZnO/graphene oxide composites that differed from those of the individual components. Enhanced electrochemical properties were detected with cyclic voltammetry, with a redox peak of the composites at 0.025 mV. Excellent antibacterial activity of ZnO/graphene oxide composites was observed with a microdilution method in which minimum inhibitory concentrations of 6.25 µg/mL for Escherichia coli and Salmonella typhimurium, 12.5 µg/mL for Bacillus subtilis, and 25 µg/mL for Enterococcus faecalis. After further study of the antibacterial mechanism, we concluded that a vast number of reactive oxygen species formed on the surface of composites, improving antibacterial properties. Keywords: graphene oxide, ZnO, characterization, antibacterial property
format	article
author	Zhong LL Yun KS
author_facet	Zhong LL Yun KS
author_sort	Zhong LL
title	Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties
title_short	Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties
title_full	Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties
title_fullStr	Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties
title_full_unstemmed	Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties
title_sort	graphene oxide-modified zno particles: synthesis, characterization, and antibacterial properties
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/08f05c4f9a604de5a87680524dff8316
work_keys_str_mv	AT zhongll grapheneoxidemodifiedznoparticlessynthesischaracterizationandantibacterialproperties AT yunks grapheneoxidemodifiedznoparticlessynthesischaracterizationandantibacterialproperties
_version_	1718402633530605568

Graphene oxide-modified ZnO particles: synthesis, characterization, and antibacterial properties

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