T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

Targeted delivery of immunomodulatory compounds to defined subsets of endogenous immune cells may improve the efficacy of combination immunotherapies. Here, the authors use PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist to deliver these payloads to T cells or via T cell...

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Autores principales:	Daniela Schmid, Chun Gwon Park, Christina A. Hartl, Nikita Subedi, Adam N. Cartwright, Regina Bou Puerto, Yiran Zheng, James Maiarana, Gordon J. Freeman, Kai W. Wucherpfennig, Darrell J. Irvine, Michael S. Goldberg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/08f1cc43b00d4985af2f7a6446427a7e
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spelling	oai:doaj.org-article:08f1cc43b00d4985af2f7a6446427a7e2021-12-02T14:40:22ZT cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity10.1038/s41467-017-01830-82041-1723https://doaj.org/article/08f1cc43b00d4985af2f7a6446427a7e2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01830-8https://doaj.org/toc/2041-1723Targeted delivery of immunomodulatory compounds to defined subsets of endogenous immune cells may improve the efficacy of combination immunotherapies. Here, the authors use PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist to deliver these payloads to T cells or via T cells to the tumor microenvironment, respectively, leading to anti-tumor efficacy in vivo.Daniela SchmidChun Gwon ParkChristina A. HartlNikita SubediAdam N. CartwrightRegina Bou PuertoYiran ZhengJames MaiaranaGordon J. FreemanKai W. WucherpfennigDarrell J. IrvineMichael S. GoldbergNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniela Schmid Chun Gwon Park Christina A. Hartl Nikita Subedi Adam N. Cartwright Regina Bou Puerto Yiran Zheng James Maiarana Gordon J. Freeman Kai W. Wucherpfennig Darrell J. Irvine Michael S. Goldberg T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
description	Targeted delivery of immunomodulatory compounds to defined subsets of endogenous immune cells may improve the efficacy of combination immunotherapies. Here, the authors use PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist to deliver these payloads to T cells or via T cells to the tumor microenvironment, respectively, leading to anti-tumor efficacy in vivo.
format	article
author	Daniela Schmid Chun Gwon Park Christina A. Hartl Nikita Subedi Adam N. Cartwright Regina Bou Puerto Yiran Zheng James Maiarana Gordon J. Freeman Kai W. Wucherpfennig Darrell J. Irvine Michael S. Goldberg
author_facet	Daniela Schmid Chun Gwon Park Christina A. Hartl Nikita Subedi Adam N. Cartwright Regina Bou Puerto Yiran Zheng James Maiarana Gordon J. Freeman Kai W. Wucherpfennig Darrell J. Irvine Michael S. Goldberg
author_sort	Daniela Schmid
title	T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
title_short	T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
title_full	T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
title_fullStr	T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
title_full_unstemmed	T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
title_sort	t cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/08f1cc43b00d4985af2f7a6446427a7e
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T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity

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