The effects of exercise training on lipid profile in patients with sarcoidosis

Abstract This study aimed to determine the use of lipid profiling to assess the effects of moderate intensity exercise training (ET) on patients with sarcoidosis. Fourteen patients with sarcoidosis (mean age, 46.0 ± 9.6 years) were examined before and after 3-week of ET programme in hospital setting...

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Autores principales:	Dariusz Jastrzebski, Beata Toczylowska, Elzbieta Zieminska, Aleksandra Zebrowska, Sabina Kostorz-Nosal, Elzbieta Swietochowska, Camillo Di Giulio, Dariusz Ziora
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08f8ab4d5983425cb78fe37332c886d7
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spelling	oai:doaj.org-article:08f8ab4d5983425cb78fe37332c886d72021-12-02T13:33:50ZThe effects of exercise training on lipid profile in patients with sarcoidosis10.1038/s41598-021-84815-42045-2322https://doaj.org/article/08f8ab4d5983425cb78fe37332c886d72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84815-4https://doaj.org/toc/2045-2322Abstract This study aimed to determine the use of lipid profiling to assess the effects of moderate intensity exercise training (ET) on patients with sarcoidosis. Fourteen patients with sarcoidosis (mean age, 46.0 ± 9.6 years) were examined before and after 3-week of ET programme in hospital settings. Symptoms (fatigue: FAS, dyspnoea: MRC), lung function tests and physical function tests (6 MWT, muscle force) were measured before and after ET. Proton nuclear magnetic resonance (NMR) spectroscopy combined with orthogonal partial least squares-discriminant analysis (OPLS-DA) was used to determine lipid profile before and after ET. Twenty-five NMR signals from lipid compounds were selected for further analysis as well as serum lipid and inflammatory markers. Three weeks of ET results in improvement of symptoms (FAS: 27.5 vs. 21.0; p < 0.001, MRC: 0.86 vs. 0.14; p = 0.002) and physical function (6MWT: 508.43 vs. 547.29; p = 0.039). OPLS-DA analysis of the lipid profiles of patients with sarcoidosis revealed differences among the samples before and after ET, including decreases in fatty acids (p < 0.017), triglycerides (p < 0.022) and total cholesterol (p < 0.020). Other changes included shifts in fatty acids oxidation products and triacylglycerol esters. A short-time, in-hospital exercise training benefits patients with sarcoidosis by enhancing their physical function. Additionally, positive effect on lipid profile was observed also in this study. It is suggested that lipid profiling could become a new prognostic method to assess effects of pulmonary rehabilitation in patients with sarcoidosis.Dariusz JastrzebskiBeata ToczylowskaElzbieta ZieminskaAleksandra ZebrowskaSabina Kostorz-NosalElzbieta SwietochowskaCamillo Di GiulioDariusz ZioraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dariusz Jastrzebski Beata Toczylowska Elzbieta Zieminska Aleksandra Zebrowska Sabina Kostorz-Nosal Elzbieta Swietochowska Camillo Di Giulio Dariusz Ziora The effects of exercise training on lipid profile in patients with sarcoidosis
description	Abstract This study aimed to determine the use of lipid profiling to assess the effects of moderate intensity exercise training (ET) on patients with sarcoidosis. Fourteen patients with sarcoidosis (mean age, 46.0 ± 9.6 years) were examined before and after 3-week of ET programme in hospital settings. Symptoms (fatigue: FAS, dyspnoea: MRC), lung function tests and physical function tests (6 MWT, muscle force) were measured before and after ET. Proton nuclear magnetic resonance (NMR) spectroscopy combined with orthogonal partial least squares-discriminant analysis (OPLS-DA) was used to determine lipid profile before and after ET. Twenty-five NMR signals from lipid compounds were selected for further analysis as well as serum lipid and inflammatory markers. Three weeks of ET results in improvement of symptoms (FAS: 27.5 vs. 21.0; p < 0.001, MRC: 0.86 vs. 0.14; p = 0.002) and physical function (6MWT: 508.43 vs. 547.29; p = 0.039). OPLS-DA analysis of the lipid profiles of patients with sarcoidosis revealed differences among the samples before and after ET, including decreases in fatty acids (p < 0.017), triglycerides (p < 0.022) and total cholesterol (p < 0.020). Other changes included shifts in fatty acids oxidation products and triacylglycerol esters. A short-time, in-hospital exercise training benefits patients with sarcoidosis by enhancing their physical function. Additionally, positive effect on lipid profile was observed also in this study. It is suggested that lipid profiling could become a new prognostic method to assess effects of pulmonary rehabilitation in patients with sarcoidosis.
format	article
author	Dariusz Jastrzebski Beata Toczylowska Elzbieta Zieminska Aleksandra Zebrowska Sabina Kostorz-Nosal Elzbieta Swietochowska Camillo Di Giulio Dariusz Ziora
author_facet	Dariusz Jastrzebski Beata Toczylowska Elzbieta Zieminska Aleksandra Zebrowska Sabina Kostorz-Nosal Elzbieta Swietochowska Camillo Di Giulio Dariusz Ziora
author_sort	Dariusz Jastrzebski
title	The effects of exercise training on lipid profile in patients with sarcoidosis
title_short	The effects of exercise training on lipid profile in patients with sarcoidosis
title_full	The effects of exercise training on lipid profile in patients with sarcoidosis
title_fullStr	The effects of exercise training on lipid profile in patients with sarcoidosis
title_full_unstemmed	The effects of exercise training on lipid profile in patients with sarcoidosis
title_sort	effects of exercise training on lipid profile in patients with sarcoidosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/08f8ab4d5983425cb78fe37332c886d7
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The effects of exercise training on lipid profile in patients with sarcoidosis

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