Update Overview of the Role of Angiopoietins in Lung Cancer

Angiogenesis is a biological process that involves the formation of new blood vessels from the existing vasculature, and it plays a fundamental role in the development and progression of several types of cancer, including lung cancer. The angiopoietin/Tie2 ligand/receptor system orchestrates vascula...

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Autores principales:	Dimitris Tsakogiannis, Asimina Nikolakopoulou, Flora Zagouri, Grigorios Stratakos, Konstantinos Syrigos, Eleni Zografos, Nikolaos Koulouris, Garyfalia Bletsa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	angiopoietins angiogenesis lung cancer non-small-cell lung cancer Ang-1 Ang-2 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/08fab478a93d491db2fcc2027f1df409
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id	oai:doaj.org-article:08fab478a93d491db2fcc2027f1df409
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spelling	oai:doaj.org-article:08fab478a93d491db2fcc2027f1df4092021-11-25T18:18:27ZUpdate Overview of the Role of Angiopoietins in Lung Cancer10.3390/medicina571111911648-91441010-660Xhttps://doaj.org/article/08fab478a93d491db2fcc2027f1df4092021-11-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1191https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144Angiogenesis is a biological process that involves the formation of new blood vessels from the existing vasculature, and it plays a fundamental role in the development and progression of several types of cancer, including lung cancer. The angiopoietin/Tie2 ligand/receptor system orchestrates vascular integrity. In particular, Angiopoietin-1 activates the endothelial cell (EC)-specific receptor tyrosine kinase,Tie2,which is essential for preserving endothelial quiescence. On the other hand, Angiopoietin-2 acts as an inhibitor of the Angiopoietin-1/Tie2 signaling pathways, thus facilitating the destabilization of quiescent endothelium in cases of inflammation and cancer. Clinical studies have proven that high levels of Angiopoietin-2 indicate the development of non-small-cell lung carcinomas (NSCLC), while high levels of Angiopoietin-2 are strongly related to tumor angiogenesis, lymphangiogenesis, metastasis, and poor prognosis. Interestingly, the association of Angiopoietin-2 levels with the type of surgical approach makes Angiopoietin-2 a valuable factor in selecting the most suitable therapeutic strategy for lung cancer patients. The role of the Angiopoietin-1 and Angiopoietin-4 levels in NSCLC development requires further investigation. The present review focuses on the clinical impact of the Angiopoietin-1, Angiopoietin-2, and Angiopoietin-4 levels in patients diagnosed with NSCLC, emphasizing the interaction between them, and how they affect the development, progression, and metastasis of lung disease. Finally, it estimates the role of angiopoietins levels in the effective therapy of lung cancer patients.Dimitris TsakogiannisAsimina NikolakopoulouFlora ZagouriGrigorios StratakosKonstantinos SyrigosEleni ZografosNikolaos KoulourisGaryfalia BletsaMDPI AGarticleangiopoietinsangiogenesislung cancernon-small-cell lung cancerAng-1Ang-2Medicine (General)R5-920ENMedicina, Vol 57, Iss 1191, p 1191 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiopoietins angiogenesis lung cancer non-small-cell lung cancer Ang-1 Ang-2 Medicine (General) R5-920
spellingShingle	angiopoietins angiogenesis lung cancer non-small-cell lung cancer Ang-1 Ang-2 Medicine (General) R5-920 Dimitris Tsakogiannis Asimina Nikolakopoulou Flora Zagouri Grigorios Stratakos Konstantinos Syrigos Eleni Zografos Nikolaos Koulouris Garyfalia Bletsa Update Overview of the Role of Angiopoietins in Lung Cancer
description	Angiogenesis is a biological process that involves the formation of new blood vessels from the existing vasculature, and it plays a fundamental role in the development and progression of several types of cancer, including lung cancer. The angiopoietin/Tie2 ligand/receptor system orchestrates vascular integrity. In particular, Angiopoietin-1 activates the endothelial cell (EC)-specific receptor tyrosine kinase,Tie2,which is essential for preserving endothelial quiescence. On the other hand, Angiopoietin-2 acts as an inhibitor of the Angiopoietin-1/Tie2 signaling pathways, thus facilitating the destabilization of quiescent endothelium in cases of inflammation and cancer. Clinical studies have proven that high levels of Angiopoietin-2 indicate the development of non-small-cell lung carcinomas (NSCLC), while high levels of Angiopoietin-2 are strongly related to tumor angiogenesis, lymphangiogenesis, metastasis, and poor prognosis. Interestingly, the association of Angiopoietin-2 levels with the type of surgical approach makes Angiopoietin-2 a valuable factor in selecting the most suitable therapeutic strategy for lung cancer patients. The role of the Angiopoietin-1 and Angiopoietin-4 levels in NSCLC development requires further investigation. The present review focuses on the clinical impact of the Angiopoietin-1, Angiopoietin-2, and Angiopoietin-4 levels in patients diagnosed with NSCLC, emphasizing the interaction between them, and how they affect the development, progression, and metastasis of lung disease. Finally, it estimates the role of angiopoietins levels in the effective therapy of lung cancer patients.
format	article
author	Dimitris Tsakogiannis Asimina Nikolakopoulou Flora Zagouri Grigorios Stratakos Konstantinos Syrigos Eleni Zografos Nikolaos Koulouris Garyfalia Bletsa
author_facet	Dimitris Tsakogiannis Asimina Nikolakopoulou Flora Zagouri Grigorios Stratakos Konstantinos Syrigos Eleni Zografos Nikolaos Koulouris Garyfalia Bletsa
author_sort	Dimitris Tsakogiannis
title	Update Overview of the Role of Angiopoietins in Lung Cancer
title_short	Update Overview of the Role of Angiopoietins in Lung Cancer
title_full	Update Overview of the Role of Angiopoietins in Lung Cancer
title_fullStr	Update Overview of the Role of Angiopoietins in Lung Cancer
title_full_unstemmed	Update Overview of the Role of Angiopoietins in Lung Cancer
title_sort	update overview of the role of angiopoietins in lung cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/08fab478a93d491db2fcc2027f1df409
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Update Overview of the Role of Angiopoietins in Lung Cancer

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