Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.

A synchronized dual-wavelength laser speckle contrast imaging (DWLSCI) system and a Doppler optical microangiography (DOMAG) system was developed to determine several ischemic parameters in the cochlea due to a systemic hypoxic challenge. DWLSCI can obtain two-dimensional data, and was used to deter...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Roberto Reif, Jia Qin, Lei Shi, Suzan Dziennis, Zhongwei Zhi, Alfred L Nuttall, Ruikang K Wang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/08fc559f70974205843705d71b16fe11
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:08fc559f70974205843705d71b16fe11
record_format	dspace
spelling	oai:doaj.org-article:08fc559f70974205843705d71b16fe112021-11-18T08:04:40ZMonitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.1932-620310.1371/journal.pone.0052041https://doaj.org/article/08fc559f70974205843705d71b16fe112012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23272205/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203A synchronized dual-wavelength laser speckle contrast imaging (DWLSCI) system and a Doppler optical microangiography (DOMAG) system was developed to determine several ischemic parameters in the cochlea due to a systemic hypoxic challenge. DWLSCI can obtain two-dimensional data, and was used to determine the relative changes in cochlear blood flow, and change in the concentrations of oxyhemoglobin (HbO), deoxyhemoglobin (Hb) and total hemoglobin (HbT) in mice. DOMAG can obtain three-dimensional data, and was used to determine the changes in cochlear blood flow with single vessel resolution. It was demonstrated that during a hypoxic challenge there was an increase in the concentrations of Hb, a decrease in the concentrations of HbO and cochlear blood flow, and a slight decrease in the concentration of HbT. Also, the rate of change in the concentrations of Hb and HbO was quantified during and after the hypoxic challenge. The ability to simultaneously measure these ischemic parameters with high spatio-temporal resolution will allow the detailed quantitative analysis of several hearing disorders, and will be useful for diagnosing and developing treatments.Roberto ReifJia QinLei ShiSuzan DziennisZhongwei ZhiAlfred L NuttallRuikang K WangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e52041 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Roberto Reif Jia Qin Lei Shi Suzan Dziennis Zhongwei Zhi Alfred L Nuttall Ruikang K Wang Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
description	A synchronized dual-wavelength laser speckle contrast imaging (DWLSCI) system and a Doppler optical microangiography (DOMAG) system was developed to determine several ischemic parameters in the cochlea due to a systemic hypoxic challenge. DWLSCI can obtain two-dimensional data, and was used to determine the relative changes in cochlear blood flow, and change in the concentrations of oxyhemoglobin (HbO), deoxyhemoglobin (Hb) and total hemoglobin (HbT) in mice. DOMAG can obtain three-dimensional data, and was used to determine the changes in cochlear blood flow with single vessel resolution. It was demonstrated that during a hypoxic challenge there was an increase in the concentrations of Hb, a decrease in the concentrations of HbO and cochlear blood flow, and a slight decrease in the concentration of HbT. Also, the rate of change in the concentrations of Hb and HbO was quantified during and after the hypoxic challenge. The ability to simultaneously measure these ischemic parameters with high spatio-temporal resolution will allow the detailed quantitative analysis of several hearing disorders, and will be useful for diagnosing and developing treatments.
format	article
author	Roberto Reif Jia Qin Lei Shi Suzan Dziennis Zhongwei Zhi Alfred L Nuttall Ruikang K Wang
author_facet	Roberto Reif Jia Qin Lei Shi Suzan Dziennis Zhongwei Zhi Alfred L Nuttall Ruikang K Wang
author_sort	Roberto Reif
title	Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
title_short	Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
title_full	Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
title_fullStr	Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
title_full_unstemmed	Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.
title_sort	monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and doppler optical microangiography system.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/08fc559f70974205843705d71b16fe11
work_keys_str_mv	AT robertoreif monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem AT jiaqin monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem AT leishi monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem AT suzandziennis monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem AT zhongweizhi monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem AT alfredlnuttall monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem AT ruikangkwang monitoringhypoxiainducedchangesincochlearbloodflowandhemoglobinconcentrationusingacombineddualwavelengthlaserspecklecontrastimaginganddoppleropticalmicroangiographysystem
_version_	1718422209679065088

Monitoring hypoxia induced changes in cochlear blood flow and hemoglobin concentration using a combined dual-wavelength laser speckle contrast imaging and Doppler optical microangiography system.

Ejemplares similares