Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts
Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorouracil and oxaliplatin-based chemotherapy through th...
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Nature Portfolio
2021
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oai:doaj.org-article:08fe478b004a4631b3a74073129531e82021-12-02T16:27:55ZPredictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts10.1038/s41467-021-25122-42041-1723https://doaj.org/article/08fe478b004a4631b3a74073129531e82021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25122-4https://doaj.org/toc/2041-1723Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorouracil and oxaliplatin-based chemotherapy through the integrative profiling of patient-derived xenograftsDeukchae NaJeesoo ChaeSung-Yup ChoWonyoung KangAhra LeeSeoyeon MinJinjoo KangMin Jung KimJaeyong ChoiWoochan LeeDongjin ShinAhrum MinYu-Jin KimKyung-Hun LeeTae-Yong KimYun-Suhk SuhSeong-Ho KongHyuk-Joon LeeWoo-Ho KimHansoo ParkSeock-Ah ImHan-Kwang YangCharles LeeJong-Il KimNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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EN |
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| spellingShingle |
Science Q Deukchae Na Jeesoo Chae Sung-Yup Cho Wonyoung Kang Ahra Lee Seoyeon Min Jinjoo Kang Min Jung Kim Jaeyong Choi Woochan Lee Dongjin Shin Ahrum Min Yu-Jin Kim Kyung-Hun Lee Tae-Yong Kim Yun-Suhk Suh Seong-Ho Kong Hyuk-Joon Lee Woo-Ho Kim Hansoo Park Seock-Ah Im Han-Kwang Yang Charles Lee Jong-Il Kim Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| description |
Gastric cancer is commonly treated by chemotherapy using 5-fluorouracil derivatives and platinum combination, but predictive biomarker remains lacking. Here, the authors develop a 30-gene prediction model to determine the responsiveness to 5-fluorouracil and oxaliplatin-based chemotherapy through the integrative profiling of patient-derived xenografts |
| format |
article |
| author |
Deukchae Na Jeesoo Chae Sung-Yup Cho Wonyoung Kang Ahra Lee Seoyeon Min Jinjoo Kang Min Jung Kim Jaeyong Choi Woochan Lee Dongjin Shin Ahrum Min Yu-Jin Kim Kyung-Hun Lee Tae-Yong Kim Yun-Suhk Suh Seong-Ho Kong Hyuk-Joon Lee Woo-Ho Kim Hansoo Park Seock-Ah Im Han-Kwang Yang Charles Lee Jong-Il Kim |
| author_facet |
Deukchae Na Jeesoo Chae Sung-Yup Cho Wonyoung Kang Ahra Lee Seoyeon Min Jinjoo Kang Min Jung Kim Jaeyong Choi Woochan Lee Dongjin Shin Ahrum Min Yu-Jin Kim Kyung-Hun Lee Tae-Yong Kim Yun-Suhk Suh Seong-Ho Kong Hyuk-Joon Lee Woo-Ho Kim Hansoo Park Seock-Ah Im Han-Kwang Yang Charles Lee Jong-Il Kim |
| author_sort |
Deukchae Na |
| title |
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| title_short |
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| title_full |
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| title_fullStr |
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| title_full_unstemmed |
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| title_sort |
predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/08fe478b004a4631b3a74073129531e8 |
| work_keys_str_mv |
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1718383974110199808 |