The microbiota in inflammatory bowel disease: current and therapeutic insights

Erin R Lane,1 Timothy L Zisman,2 David L Suskind1 1Division of Gastroenterology and Hepatology, Seattle Children’s Hospital, 2Division of Gastroenterology, University of Washington, Seattle, WA, USA Abstract: Inflammatory bowel disease is a heterogeneous group of chronic disorders that res...

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Autores principales:	Lane ER, Zisman TL, Suskind DL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Crohn’s disease Ulcerative colitis Microbiome Fecal Microbiota Transplantation Enteral nutrition Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/08ffeb74be7a4c2f898158b410953c3a
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spelling	oai:doaj.org-article:08ffeb74be7a4c2f898158b410953c3a2021-12-02T07:59:07ZThe microbiota in inflammatory bowel disease: current and therapeutic insights1178-7031https://doaj.org/article/08ffeb74be7a4c2f898158b410953c3a2017-06-01T00:00:00Zhttps://www.dovepress.com/the-microbiota-in-inflammatory-bowel-disease-current-and-therapeutic-i-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Erin R Lane,1 Timothy L Zisman,2 David L Suskind1 1Division of Gastroenterology and Hepatology, Seattle Children’s Hospital, 2Division of Gastroenterology, University of Washington, Seattle, WA, USA Abstract: Inflammatory bowel disease is a heterogeneous group of chronic disorders that result from the interaction of the intestinal immune system with the gut microbiome. Until recently, most investigative efforts and therapeutic breakthroughs were centered on understanding and manipulating the altered mucosal immune response that characterizes these diseases. However, more recent studies have highlighted the important role of environmental factors, and in particular the microbiota, in disease onset and disease exacerbation. Advances in genomic sequencing technology and bioinformatics have facilitated an explosion of investigative inquiries into the composition and function of the intestinal microbiome in health and disease and have advanced our understanding of the interplay between the gut microbiota and the host immune system. The gut microbiome is dynamic and changes with age and in response to diet, antibiotics and other environmental factors, and these alterations in the microbiome contribute to disease onset and exacerbation. Strategies to manipulate the microbiome through diet, probiotics, antibiotics or fecal microbiota transplantation may potentially be used therapeutically to influence modulate disease activity. This review will characterize the factors involved in the development of the intestinal microbiome and will describe the typical alterations in the microbiota that are characteristic of inflammatory bowel disease. Additionally, this manuscript will summarize the early but promising literature on the role of the gut microbiota in the pathogenesis of inflammatory bowel disease with implications for utilizing this data for diagnostic or therapeutic application in the clinical management of patients with these diseases. Keywords: Crohn’s disease, ulcerative colitis, microbiome, fecal microbiota transplantation, enteral nutrition, specific carbohydrate dietLane ERZisman TLSuskind DLDove Medical PressarticleCrohn’s diseaseUlcerative colitisMicrobiomeFecal Microbiota TransplantationEnteral nutritionPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 10, Pp 63-73 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crohn’s disease Ulcerative colitis Microbiome Fecal Microbiota Transplantation Enteral nutrition Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Crohn’s disease Ulcerative colitis Microbiome Fecal Microbiota Transplantation Enteral nutrition Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Lane ER Zisman TL Suskind DL The microbiota in inflammatory bowel disease: current and therapeutic insights
description	Erin R Lane,1 Timothy L Zisman,2 David L Suskind1 1Division of Gastroenterology and Hepatology, Seattle Children’s Hospital, 2Division of Gastroenterology, University of Washington, Seattle, WA, USA Abstract: Inflammatory bowel disease is a heterogeneous group of chronic disorders that result from the interaction of the intestinal immune system with the gut microbiome. Until recently, most investigative efforts and therapeutic breakthroughs were centered on understanding and manipulating the altered mucosal immune response that characterizes these diseases. However, more recent studies have highlighted the important role of environmental factors, and in particular the microbiota, in disease onset and disease exacerbation. Advances in genomic sequencing technology and bioinformatics have facilitated an explosion of investigative inquiries into the composition and function of the intestinal microbiome in health and disease and have advanced our understanding of the interplay between the gut microbiota and the host immune system. The gut microbiome is dynamic and changes with age and in response to diet, antibiotics and other environmental factors, and these alterations in the microbiome contribute to disease onset and exacerbation. Strategies to manipulate the microbiome through diet, probiotics, antibiotics or fecal microbiota transplantation may potentially be used therapeutically to influence modulate disease activity. This review will characterize the factors involved in the development of the intestinal microbiome and will describe the typical alterations in the microbiota that are characteristic of inflammatory bowel disease. Additionally, this manuscript will summarize the early but promising literature on the role of the gut microbiota in the pathogenesis of inflammatory bowel disease with implications for utilizing this data for diagnostic or therapeutic application in the clinical management of patients with these diseases. Keywords: Crohn’s disease, ulcerative colitis, microbiome, fecal microbiota transplantation, enteral nutrition, specific carbohydrate diet
format	article
author	Lane ER Zisman TL Suskind DL
author_facet	Lane ER Zisman TL Suskind DL
author_sort	Lane ER
title	The microbiota in inflammatory bowel disease: current and therapeutic insights
title_short	The microbiota in inflammatory bowel disease: current and therapeutic insights
title_full	The microbiota in inflammatory bowel disease: current and therapeutic insights
title_fullStr	The microbiota in inflammatory bowel disease: current and therapeutic insights
title_full_unstemmed	The microbiota in inflammatory bowel disease: current and therapeutic insights
title_sort	microbiota in inflammatory bowel disease: current and therapeutic insights
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/08ffeb74be7a4c2f898158b410953c3a
work_keys_str_mv	AT laneer themicrobiotaininflammatoryboweldiseasecurrentandtherapeuticinsights AT zismantl themicrobiotaininflammatoryboweldiseasecurrentandtherapeuticinsights AT suskinddl themicrobiotaininflammatoryboweldiseasecurrentandtherapeuticinsights AT laneer microbiotaininflammatoryboweldiseasecurrentandtherapeuticinsights AT zismantl microbiotaininflammatoryboweldiseasecurrentandtherapeuticinsights AT suskinddl microbiotaininflammatoryboweldiseasecurrentandtherapeuticinsights
_version_	1718398704648454144

The microbiota in inflammatory bowel disease: current and therapeutic insights

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