Spermatogonial stem cell transplantation and male infertility: Current status and future directions

Objective: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. Materials and methods: We performed a search for publications add...

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Autores principales:	Connor M. Forbes, Ryan Flannigan, Peter N. Schlegel
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/0902a5da81b640ff94b274156f3eca82
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spelling	oai:doaj.org-article:0902a5da81b640ff94b274156f3eca822021-12-02T13:03:31ZSpermatogonial stem cell transplantation and male infertility: Current status and future directions2090-598X10.1016/j.aju.2017.11.015https://doaj.org/article/0902a5da81b640ff94b274156f3eca822018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17301493https://doaj.org/toc/2090-598XObjective: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. Materials and methods: We performed a search for publications addressing spermatogonial stem cell transplantation in the treatment of male infertility. The search engines PubMed and Google Scholar were used from 1990 to 2017. Search terms were relevant for spermatogonial stem cell therapies. Titles of publications were screened for relevance; abstracts were read, if related and full papers were reviewed for directly pertinent original research. Results: In all, 58 papers were found to be relevant to this review, and were included in appropriate subheadings. This review discusses the various techniques that SSCs are being investigated to treat forms of male infertility. Conclusions: Evidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research. Keywords: Non-obstructive azoospermia, Fertility preservation, Onco-fertility, Male infertility, Stem cell therapy, AllograftConnor M. ForbesRyan FlanniganPeter N. SchlegelTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss 1, Pp 171-180 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Connor M. Forbes Ryan Flannigan Peter N. Schlegel Spermatogonial stem cell transplantation and male infertility: Current status and future directions
description	Objective: To summarise the current state of research into spermatogonial stem cell (SSC) therapies with a focus on future directions, as SSCs show promise as a source for preserving or initiating fertility in otherwise infertile men. Materials and methods: We performed a search for publications addressing spermatogonial stem cell transplantation in the treatment of male infertility. The search engines PubMed and Google Scholar were used from 1990 to 2017. Search terms were relevant for spermatogonial stem cell therapies. Titles of publications were screened for relevance; abstracts were read, if related and full papers were reviewed for directly pertinent original research. Results: In all, 58 papers were found to be relevant to this review, and were included in appropriate subheadings. This review discusses the various techniques that SSCs are being investigated to treat forms of male infertility. Conclusions: Evidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research. Keywords: Non-obstructive azoospermia, Fertility preservation, Onco-fertility, Male infertility, Stem cell therapy, Allograft
format	article
author	Connor M. Forbes Ryan Flannigan Peter N. Schlegel
author_facet	Connor M. Forbes Ryan Flannigan Peter N. Schlegel
author_sort	Connor M. Forbes
title	Spermatogonial stem cell transplantation and male infertility: Current status and future directions
title_short	Spermatogonial stem cell transplantation and male infertility: Current status and future directions
title_full	Spermatogonial stem cell transplantation and male infertility: Current status and future directions
title_fullStr	Spermatogonial stem cell transplantation and male infertility: Current status and future directions
title_full_unstemmed	Spermatogonial stem cell transplantation and male infertility: Current status and future directions
title_sort	spermatogonial stem cell transplantation and male infertility: current status and future directions
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/0902a5da81b640ff94b274156f3eca82
work_keys_str_mv	AT connormforbes spermatogonialstemcelltransplantationandmaleinfertilitycurrentstatusandfuturedirections AT ryanflannigan spermatogonialstemcelltransplantationandmaleinfertilitycurrentstatusandfuturedirections AT peternschlegel spermatogonialstemcelltransplantationandmaleinfertilitycurrentstatusandfuturedirections
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Spermatogonial stem cell transplantation and male infertility: Current status and future directions

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