Dendritic cells in the pathogenesis of viral hepatitis C

Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in most (up to 85%) infected patients and increases the risk for developing liver cirrhosis, hepatocellular carcinoma, and severe extrahepatic manifestations. The mechanisms of HCV persistence are larg...

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Autores principales:	Elena Removna Chernykh, Ekaterina Alexandrovna Oleynik, Olga Yur’evna Leplina, Natalya Mihaylovna Starostina, Alexander Anatolievich Ostanin
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2019
Materias:	dendritic cells mdcs pdcs mo-dcs innate immunity, adaptive immunity t cell response hcv-antigens dc vaccines hcv-infection Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/0903b593b7b243a7be4301014d90236d
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spelling	oai:doaj.org-article:0903b593b7b243a7be4301014d90236d2021-11-22T07:09:52ZDendritic cells in the pathogenesis of viral hepatitis C2220-76192313-739810.15789/2220-7619-2019-2-239-252https://doaj.org/article/0903b593b7b243a7be4301014d90236d2019-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/726https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in most (up to 85%) infected patients and increases the risk for developing liver cirrhosis, hepatocellular carcinoma, and severe extrahepatic manifestations. The mechanisms of HCV persistence are largely related to the inefficient antiviral response of the host immune system. The effective clearance of the virus requires early activation of innate immune system together with the induction of a strong multiepitopic adoptive T cell response and long-term antiviral memory. Dendritic cells (DCs), which represent a heterogeneous population of antigen-presenting cells, contribute to the production of type I interferon, activate natural killer cells and induce adoptive immune response thus playing a major role in antiviral defense. In this case, DCs dysfunction in HCV-infection is considered to be the one of the mechanism that allows the virus to escape from the immune surveillance. The present review includes current data focusing on the role of DCs in the anti-HCV immune response and highlights a number of key issues related to the phenotypic and functional changes of various DC subpopulations in HCV-infection, the mechanisms of DC impairments and the prospects for treatment of chronic hepatitis C based on the use of ex vivo generated DCs.Elena Removna ChernykhEkaterina Alexandrovna OleynikOlga Yur’evna LeplinaNatalya Mihaylovna StarostinaAlexander Anatolievich OstaninSankt-Peterburg : NIIÈM imeni Pasteraarticledendritic cellsmdcspdcsmo-dcsinnate immunity, adaptive immunityt cell responsehcv-antigensdc vaccineshcv-infectionInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 2, Pp 239-252 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	dendritic cells mdcs pdcs mo-dcs innate immunity, adaptive immunity t cell response hcv-antigens dc vaccines hcv-infection Infectious and parasitic diseases RC109-216
spellingShingle	dendritic cells mdcs pdcs mo-dcs innate immunity, adaptive immunity t cell response hcv-antigens dc vaccines hcv-infection Infectious and parasitic diseases RC109-216 Elena Removna Chernykh Ekaterina Alexandrovna Oleynik Olga Yur’evna Leplina Natalya Mihaylovna Starostina Alexander Anatolievich Ostanin Dendritic cells in the pathogenesis of viral hepatitis C
description	Infection with hepatitis C virus (HCV) is a public health problem; it establishes a chronic course in most (up to 85%) infected patients and increases the risk for developing liver cirrhosis, hepatocellular carcinoma, and severe extrahepatic manifestations. The mechanisms of HCV persistence are largely related to the inefficient antiviral response of the host immune system. The effective clearance of the virus requires early activation of innate immune system together with the induction of a strong multiepitopic adoptive T cell response and long-term antiviral memory. Dendritic cells (DCs), which represent a heterogeneous population of antigen-presenting cells, contribute to the production of type I interferon, activate natural killer cells and induce adoptive immune response thus playing a major role in antiviral defense. In this case, DCs dysfunction in HCV-infection is considered to be the one of the mechanism that allows the virus to escape from the immune surveillance. The present review includes current data focusing on the role of DCs in the anti-HCV immune response and highlights a number of key issues related to the phenotypic and functional changes of various DC subpopulations in HCV-infection, the mechanisms of DC impairments and the prospects for treatment of chronic hepatitis C based on the use of ex vivo generated DCs.
format	article
author	Elena Removna Chernykh Ekaterina Alexandrovna Oleynik Olga Yur’evna Leplina Natalya Mihaylovna Starostina Alexander Anatolievich Ostanin
author_facet	Elena Removna Chernykh Ekaterina Alexandrovna Oleynik Olga Yur’evna Leplina Natalya Mihaylovna Starostina Alexander Anatolievich Ostanin
author_sort	Elena Removna Chernykh
title	Dendritic cells in the pathogenesis of viral hepatitis C
title_short	Dendritic cells in the pathogenesis of viral hepatitis C
title_full	Dendritic cells in the pathogenesis of viral hepatitis C
title_fullStr	Dendritic cells in the pathogenesis of viral hepatitis C
title_full_unstemmed	Dendritic cells in the pathogenesis of viral hepatitis C
title_sort	dendritic cells in the pathogenesis of viral hepatitis c
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2019
url	https://doaj.org/article/0903b593b7b243a7be4301014d90236d
work_keys_str_mv	AT elenaremovnachernykh dendriticcellsinthepathogenesisofviralhepatitisc AT ekaterinaalexandrovnaoleynik dendriticcellsinthepathogenesisofviralhepatitisc AT olgayurevnaleplina dendriticcellsinthepathogenesisofviralhepatitisc AT natalyamihaylovnastarostina dendriticcellsinthepathogenesisofviralhepatitisc AT alexanderanatolievichostanin dendriticcellsinthepathogenesisofviralhepatitisc
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Dendritic cells in the pathogenesis of viral hepatitis C

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