[11] Oncological outcomes of partial nephrectomy in Algeria

Objective: To investigate the oncological outcomes of partial nephrectomy (PN) in Algeria, as according to data from the World Health Organisation 2012 renal cell carcinoma (RCC) is ranked as the 14th most common cancer in Algeria in both sexes, and PN has comparable oncological control to radical n...

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Autores principales:	Samir Bouras, Samir Yebi
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/09061b93876e44808e2b832823fdbe17
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spelling	oai:doaj.org-article:09061b93876e44808e2b832823fdbe172021-12-02T12:24:08Z[11] Oncological outcomes of partial nephrectomy in Algeria2090-598X10.1016/j.aju.2018.10.058https://doaj.org/article/09061b93876e44808e2b832823fdbe172018-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X18301529https://doaj.org/toc/2090-598XObjective: To investigate the oncological outcomes of partial nephrectomy (PN) in Algeria, as according to data from the World Health Organisation 2012 renal cell carcinoma (RCC) is ranked as the 14th most common cancer in Algeria in both sexes, and PN has comparable oncological control to radical nephrectomy. Methods: Retrospective bi-centre study, from June 2012 to December 2016. In all, 112 patients had a PN for RCC. Amongst these patients, 80 (71.4%) had RCC confirmed at pathology. The statistical study was carried out using SPSS® version 20 software (SPSS Inc., IBM Corp., Armonk, NY, USA). Results: The mean (range) age was 57.3 (24–85) years and there were more women [48 (60%)]. The mean (range) histopathological size was 48 (20–90) mm, and the pathological typing was: clear cell carcinoma in 34 cases (51.3%), papillary cell carcinoma in 20 (16%), and chromophobe carcinoma in 18 (22.5%). There were positive surgical margins (PSM) in 11/80 cases (13.7%). Of the 80 RCC patients, 66 (82.5%), three (3.8%), nine (11.3%) and one (1.3%) had stage pT1, pT2, pT3a, and pT4, respectively. Most of the RCC patients [67 (83.8%)] were in the Fuhrman low-grade group. After a mean (range) follow-up of 43.2 (18–72) months, we had a recurrence rate of 4.5% (one local recurrence by multifocality, three cases of regional hilar adenopathy, one of whom also presented mediastinal and pulmonary lymph node metastases). Bone metastasis and a hepatic localisation occurred in two patients, giving a metastasis rate of 3.4%. Conclusion: Despite a high rate of PSM, all cases of recurrence occurred on negative margins, as was the case of pulmonary metastases. RCC is known for its multifocality, which is estimated between 5% and 25%. Several factors may explain bone and hepatic metastasis, including PSM and high Fuhrman grade. Indeed, PSM are not considered as an independent factor of recurrence in several series. Overall, 75 (93.7%) of all the RCC patients, and all 11 patients with PSM were alive at the end of the study. More time is needed, as well as other studies, to better evaluate the oncological profile of these RCCs in Algeria.Samir BourasSamir YebiTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 16, Iss , Pp S7- (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Samir Bouras Samir Yebi [11] Oncological outcomes of partial nephrectomy in Algeria
description	Objective: To investigate the oncological outcomes of partial nephrectomy (PN) in Algeria, as according to data from the World Health Organisation 2012 renal cell carcinoma (RCC) is ranked as the 14th most common cancer in Algeria in both sexes, and PN has comparable oncological control to radical nephrectomy. Methods: Retrospective bi-centre study, from June 2012 to December 2016. In all, 112 patients had a PN for RCC. Amongst these patients, 80 (71.4%) had RCC confirmed at pathology. The statistical study was carried out using SPSS® version 20 software (SPSS Inc., IBM Corp., Armonk, NY, USA). Results: The mean (range) age was 57.3 (24–85) years and there were more women [48 (60%)]. The mean (range) histopathological size was 48 (20–90) mm, and the pathological typing was: clear cell carcinoma in 34 cases (51.3%), papillary cell carcinoma in 20 (16%), and chromophobe carcinoma in 18 (22.5%). There were positive surgical margins (PSM) in 11/80 cases (13.7%). Of the 80 RCC patients, 66 (82.5%), three (3.8%), nine (11.3%) and one (1.3%) had stage pT1, pT2, pT3a, and pT4, respectively. Most of the RCC patients [67 (83.8%)] were in the Fuhrman low-grade group. After a mean (range) follow-up of 43.2 (18–72) months, we had a recurrence rate of 4.5% (one local recurrence by multifocality, three cases of regional hilar adenopathy, one of whom also presented mediastinal and pulmonary lymph node metastases). Bone metastasis and a hepatic localisation occurred in two patients, giving a metastasis rate of 3.4%. Conclusion: Despite a high rate of PSM, all cases of recurrence occurred on negative margins, as was the case of pulmonary metastases. RCC is known for its multifocality, which is estimated between 5% and 25%. Several factors may explain bone and hepatic metastasis, including PSM and high Fuhrman grade. Indeed, PSM are not considered as an independent factor of recurrence in several series. Overall, 75 (93.7%) of all the RCC patients, and all 11 patients with PSM were alive at the end of the study. More time is needed, as well as other studies, to better evaluate the oncological profile of these RCCs in Algeria.
format	article
author	Samir Bouras Samir Yebi
author_facet	Samir Bouras Samir Yebi
author_sort	Samir Bouras
title	[11] Oncological outcomes of partial nephrectomy in Algeria
title_short	[11] Oncological outcomes of partial nephrectomy in Algeria
title_full	[11] Oncological outcomes of partial nephrectomy in Algeria
title_fullStr	[11] Oncological outcomes of partial nephrectomy in Algeria
title_full_unstemmed	[11] Oncological outcomes of partial nephrectomy in Algeria
title_sort	[11] oncological outcomes of partial nephrectomy in algeria
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/09061b93876e44808e2b832823fdbe17
work_keys_str_mv	AT samirbouras 11oncologicaloutcomesofpartialnephrectomyinalgeria AT samiryebi 11oncologicaloutcomesofpartialnephrectomyinalgeria
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[11] Oncological outcomes of partial nephrectomy in Algeria

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