Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population

Na Yang, Liyun He, Yuxiu Li, Lingling Xu, Fan Ping, Wei Li, Huabing Zhang Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People&rsquo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yang N, He L, Li Y, Xu L, Ping F, Li W, Zhang H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diet magnesium intake metabolic syndrome insulin resistance chinese population mediation effect Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/090770f406ca491a8e62f92f55ccb80d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:090770f406ca491a8e62f92f55ccb80d
record_format	dspace
spelling	oai:doaj.org-article:090770f406ca491a8e62f92f55ccb80d2021-12-02T09:21:24ZReduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population1178-7007https://doaj.org/article/090770f406ca491a8e62f92f55ccb80d2020-07-01T00:00:00Zhttps://www.dovepress.com/reduced-insulin-resistance-partly-mediated-the-association-of-high-die-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Na Yang, Liyun He, Yuxiu Li, Lingling Xu, Fan Ping, Wei Li, Huabing Zhang Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Huabing ZhangPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaTel/ Fax +-86-010-69155073Email huabingzhangchn@163.comPurpose: High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). The aim of the cross-sectional analysis was to evaluate the association between dietary magnesium intake, IR, and MetS using data from China Health and Nutrition Survey.Methods: Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IR and the prevalence of MetS across the quartile categories of dietary magnesium intake. In addition, we used the macro PROCESS to perform the mediation analyses.Results: A total of 8120 participants were included in the final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals [CI] 0.376 to 0.502). The prevalence of the MetS was 38.6%, 28.9%, 22.5%, and 16.5% for increasing quartiles of dietary magnesium intake (p < 0.001). The mediation model analysis displayed that insulin resistance mediated the effect of dietary magnesium on MetS. The direct effect and indirect effect of dietary magnesium on MetS were found significant, and the calculated percentage of mediation by insulin resistance was 19.6%.Conclusion: Our study demonstrated a significant and independent negative relationship among weight-adjusted dietary magnesium intake, HOMA-IR, and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS.Keywords: diet magnesium intake, metabolic syndrome, insulin resistance, Chinese population, mediation effectYang NHe LLi YXu LPing FLi WZhang HDove Medical Pressarticlediet magnesium intakemetabolic syndromeinsulin resistancechinese populationmediation effectSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 2541-2550 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diet magnesium intake metabolic syndrome insulin resistance chinese population mediation effect Specialties of internal medicine RC581-951
spellingShingle	diet magnesium intake metabolic syndrome insulin resistance chinese population mediation effect Specialties of internal medicine RC581-951 Yang N He L Li Y Xu L Ping F Li W Zhang H Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
description	Na Yang, Liyun He, Yuxiu Li, Lingling Xu, Fan Ping, Wei Li, Huabing Zhang Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Huabing ZhangPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaTel/ Fax +-86-010-69155073Email huabingzhangchn@163.comPurpose: High dietary magnesium intake may reduce insulin resistance (IR) and metabolic syndrome (MetS). The aim of the cross-sectional analysis was to evaluate the association between dietary magnesium intake, IR, and MetS using data from China Health and Nutrition Survey.Methods: Dietary magnesium intake was defined as daily dietary magnesium intake divided by body weight. Logistic regression analysis was used to calculate the odds ratio (OR) for IR and the prevalence of MetS across the quartile categories of dietary magnesium intake. In addition, we used the macro PROCESS to perform the mediation analyses.Results: A total of 8120 participants were included in the final analysis. We found a significant negative association between dietary magnesium intake and IR, the multivariable-adjusted OR for HOMA-IR comparing the highest to the lowest quartile of dietary magnesium intake was 0.435 (95% confidence intervals [CI] 0.376 to 0.502). The prevalence of the MetS was 38.6%, 28.9%, 22.5%, and 16.5% for increasing quartiles of dietary magnesium intake (p < 0.001). The mediation model analysis displayed that insulin resistance mediated the effect of dietary magnesium on MetS. The direct effect and indirect effect of dietary magnesium on MetS were found significant, and the calculated percentage of mediation by insulin resistance was 19.6%.Conclusion: Our study demonstrated a significant and independent negative relationship among weight-adjusted dietary magnesium intake, HOMA-IR, and MetS in a large Chinese population. IR partly mediated the relationship between dietary magnesium intake and MetS.Keywords: diet magnesium intake, metabolic syndrome, insulin resistance, Chinese population, mediation effect
format	article
author	Yang N He L Li Y Xu L Ping F Li W Zhang H
author_facet	Yang N He L Li Y Xu L Ping F Li W Zhang H
author_sort	Yang N
title	Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
title_short	Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
title_full	Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
title_fullStr	Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
title_full_unstemmed	Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population
title_sort	reduced insulin resistance partly mediated the association of high dietary magnesium intake with less metabolic syndrome in a large chinese population
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/090770f406ca491a8e62f92f55ccb80d
work_keys_str_mv	AT yangn reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation AT hel reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation AT liy reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation AT xul reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation AT pingf reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation AT liw reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation AT zhangh reducedinsulinresistancepartlymediatedtheassociationofhighdietarymagnesiumintakewithlessmetabolicsyndromeinalargechinesepopulation
_version_	1718398104611323904

Reduced Insulin Resistance Partly Mediated the Association of High Dietary Magnesium Intake with Less Metabolic Syndrome in a Large Chinese Population

Ejemplares similares