Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study

Abstract Proteinuria is one of the well-known risk factors for cardiovascular disease. However the impact of proteinuria on the incidence of atrial fibrillation (AF) is unclear. In this study, we investigated the association between proteinuria detected using urine dipstick test and the risk of AF....

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Autores principales:	Woo-Hyun Lim, Eue -Keun Choi, Kyung-Do Han, Tae-Min Rhee, Hyun-Jung Lee, So-Ryoung Lee, Si-Hyuck Kang, Myung-Jin Cha, Seil Oh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0908e8608dd040768b432a395d7f9fba
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spelling	oai:doaj.org-article:0908e8608dd040768b432a395d7f9fba2021-12-02T11:52:19ZProteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study10.1038/s41598-017-06579-02045-2322https://doaj.org/article/0908e8608dd040768b432a395d7f9fba2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06579-0https://doaj.org/toc/2045-2322Abstract Proteinuria is one of the well-known risk factors for cardiovascular disease. However the impact of proteinuria on the incidence of atrial fibrillation (AF) is unclear. In this study, we investigated the association between proteinuria detected using urine dipstick test and the risk of AF. A total of 18,201,275 individuals were analyzed, who had no prior AF and had received biennial health checkups provided by the National Health Insurance Service between 2005 and 2008 in Korea. Incidences of AF were ascertained through the end of 2015. During a mean follow-up of 9.6 years, a total of 324,764 (1.8%) developed AF (1.86 per 1,000 person-years). In Cox regression models, proteinuria was associated with an increased risk of AF: adjusted HR and 95% CI of AF occurrence were 1.13 (1.10–1.16), 1.34 (1.31–1.38), 1.53 (1.48–1.58), 1.82 (1.71–1.94), and 1.86 (1.61–2.16) in individuals with trace, 1+, 2+, 3+, and 4+ proteinuria, respectively, compared with those without proteinuria. The result was consistent even after additional adjustment for estimated glomerular filtration rate. In addition, the risk of AF further increased or decreased according to the follow-up dipstick test results. Thus, proteinuria measured with a dipstick test might be considered a potent risk factor for AF development.Woo-Hyun LimEue -Keun ChoiKyung-Do HanTae-Min RheeHyun-Jung LeeSo-Ryoung LeeSi-Hyuck KangMyung-Jin ChaSeil OhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Woo-Hyun Lim Eue -Keun Choi Kyung-Do Han Tae-Min Rhee Hyun-Jung Lee So-Ryoung Lee Si-Hyuck Kang Myung-Jin Cha Seil Oh Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study
description	Abstract Proteinuria is one of the well-known risk factors for cardiovascular disease. However the impact of proteinuria on the incidence of atrial fibrillation (AF) is unclear. In this study, we investigated the association between proteinuria detected using urine dipstick test and the risk of AF. A total of 18,201,275 individuals were analyzed, who had no prior AF and had received biennial health checkups provided by the National Health Insurance Service between 2005 and 2008 in Korea. Incidences of AF were ascertained through the end of 2015. During a mean follow-up of 9.6 years, a total of 324,764 (1.8%) developed AF (1.86 per 1,000 person-years). In Cox regression models, proteinuria was associated with an increased risk of AF: adjusted HR and 95% CI of AF occurrence were 1.13 (1.10–1.16), 1.34 (1.31–1.38), 1.53 (1.48–1.58), 1.82 (1.71–1.94), and 1.86 (1.61–2.16) in individuals with trace, 1+, 2+, 3+, and 4+ proteinuria, respectively, compared with those without proteinuria. The result was consistent even after additional adjustment for estimated glomerular filtration rate. In addition, the risk of AF further increased or decreased according to the follow-up dipstick test results. Thus, proteinuria measured with a dipstick test might be considered a potent risk factor for AF development.
format	article
author	Woo-Hyun Lim Eue -Keun Choi Kyung-Do Han Tae-Min Rhee Hyun-Jung Lee So-Ryoung Lee Si-Hyuck Kang Myung-Jin Cha Seil Oh
author_facet	Woo-Hyun Lim Eue -Keun Choi Kyung-Do Han Tae-Min Rhee Hyun-Jung Lee So-Ryoung Lee Si-Hyuck Kang Myung-Jin Cha Seil Oh
author_sort	Woo-Hyun Lim
title	Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study
title_short	Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study
title_full	Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study
title_fullStr	Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study
title_full_unstemmed	Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study
title_sort	proteinuria detected by urine dipstick test as a risk factor for atrial fibrillation: a nationwide population-based study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0908e8608dd040768b432a395d7f9fba
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Proteinuria Detected by Urine Dipstick Test as a Risk Factor for Atrial Fibrillation: A Nationwide Population-Based Study

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