Inhalation drug delivery devices: technology update

Mariam Ibrahim, Rahul Verma, Lucila Garcia-ContrerasDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAAbstract: The pulmonary route of administration has proven to be effective in local and systemic delivery of misce...

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Main Authors:	Ibrahim M, Verma R, Garcia-Contreras L
Format:	article
Language:	EN
Published:	Dove Medical Press 2015
Subjects:	Medical technology R855-855.5
Online Access:	https://doaj.org/article/090c6406977b4429a89216152a873a51
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id	oai:doaj.org-article:090c6406977b4429a89216152a873a51
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spelling	oai:doaj.org-article:090c6406977b4429a89216152a873a512021-12-02T01:12:28ZInhalation drug delivery devices: technology update1179-1470https://doaj.org/article/090c6406977b4429a89216152a873a512015-02-01T00:00:00Zhttp://www.dovepress.com/inhalation-drug-delivery-devices-technology-update-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470 Mariam Ibrahim, Rahul Verma, Lucila Garcia-ContrerasDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAAbstract: The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desired effect or adverse outcomes is the incorrect use of the device due to lack of training in how to use the device or how to coordinate actuation and aerosol inhalation. This review summarizes the structural and mechanical features of aerosol delivery devices with respect to mechanisms of aerosol generation, their use with different formulations, and their advantages and limitations. A technological update of the current state-of-the-art designs proposed to overcome current challenges of existing devices is also provided.Keywords: pulmonary delivery, asthma, nebulizers, metered dose inhaler, dry powder inhalerIbrahim MVerma RGarcia-Contreras LDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2015, Iss default, Pp 131-139 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Ibrahim M Verma R Garcia-Contreras L Inhalation drug delivery devices: technology update
description	Mariam Ibrahim, Rahul Verma, Lucila Garcia-ContrerasDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, OK, USAAbstract: The pulmonary route of administration has proven to be effective in local and systemic delivery of miscellaneous drugs and biopharmaceuticals to treat pulmonary and non-pulmonary diseases. A successful pulmonary administration requires a harmonic interaction between the drug formulation, the inhaler device, and the patient. However, the biggest single problem that accounts for the lack of desired effect or adverse outcomes is the incorrect use of the device due to lack of training in how to use the device or how to coordinate actuation and aerosol inhalation. This review summarizes the structural and mechanical features of aerosol delivery devices with respect to mechanisms of aerosol generation, their use with different formulations, and their advantages and limitations. A technological update of the current state-of-the-art designs proposed to overcome current challenges of existing devices is also provided.Keywords: pulmonary delivery, asthma, nebulizers, metered dose inhaler, dry powder inhaler
format	article
author	Ibrahim M Verma R Garcia-Contreras L
author_facet	Ibrahim M Verma R Garcia-Contreras L
author_sort	Ibrahim M
title	Inhalation drug delivery devices: technology update
title_short	Inhalation drug delivery devices: technology update
title_full	Inhalation drug delivery devices: technology update
title_fullStr	Inhalation drug delivery devices: technology update
title_full_unstemmed	Inhalation drug delivery devices: technology update
title_sort	inhalation drug delivery devices: technology update
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/090c6406977b4429a89216152a873a51
work_keys_str_mv	AT ibrahimm inhalationdrugdeliverydevicestechnologyupdate AT vermar inhalationdrugdeliverydevicestechnologyupdate AT garciacontrerasl inhalationdrugdeliverydevicestechnologyupdate
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Inhalation drug delivery devices: technology update

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