Spiral Form of the Human Cochlea Results from Spatial Constraints

Abstract The human inner ear has an intricate spiral shape often compared to shells of mollusks, particularly to the nautilus shell. It has inspired many functional hearing theories. The reasons for this complex geometry remain unresolved. We digitized 138 human cochleae at microscopic resolution an...

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Autores principales:	M. Pietsch, L. Aguirre Dávila, P. Erfurt, E. Avci, T. Lenarz, A. Kral
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/091231398d0f4c658b3c5b78c2ea14f2
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id	oai:doaj.org-article:091231398d0f4c658b3c5b78c2ea14f2
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spelling	oai:doaj.org-article:091231398d0f4c658b3c5b78c2ea14f22021-12-02T16:06:35ZSpiral Form of the Human Cochlea Results from Spatial Constraints10.1038/s41598-017-07795-42045-2322https://doaj.org/article/091231398d0f4c658b3c5b78c2ea14f22017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07795-4https://doaj.org/toc/2045-2322Abstract The human inner ear has an intricate spiral shape often compared to shells of mollusks, particularly to the nautilus shell. It has inspired many functional hearing theories. The reasons for this complex geometry remain unresolved. We digitized 138 human cochleae at microscopic resolution and observed an astonishing interindividual variability in the shape. A 3D analytical cochlear model was developed that fits the analyzed data with high precision. The cochlear geometry neither matched a proposed function, namely sound focusing similar to a whispering gallery, nor did it have the form of a nautilus. Instead, the innate cochlear blueprint and its actual ontogenetic variants were determined by spatial constraints and resulted from an efficient packing of the cochlear duct within the petrous bone. The analytical model predicts well the individual 3D cochlear geometry from few clinical measures and represents a clinical tool for an individualized approach to neurosensory restoration with cochlear implants.M. PietschL. Aguirre DávilaP. ErfurtE. AvciT. LenarzA. KralNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Pietsch L. Aguirre Dávila P. Erfurt E. Avci T. Lenarz A. Kral Spiral Form of the Human Cochlea Results from Spatial Constraints
description	Abstract The human inner ear has an intricate spiral shape often compared to shells of mollusks, particularly to the nautilus shell. It has inspired many functional hearing theories. The reasons for this complex geometry remain unresolved. We digitized 138 human cochleae at microscopic resolution and observed an astonishing interindividual variability in the shape. A 3D analytical cochlear model was developed that fits the analyzed data with high precision. The cochlear geometry neither matched a proposed function, namely sound focusing similar to a whispering gallery, nor did it have the form of a nautilus. Instead, the innate cochlear blueprint and its actual ontogenetic variants were determined by spatial constraints and resulted from an efficient packing of the cochlear duct within the petrous bone. The analytical model predicts well the individual 3D cochlear geometry from few clinical measures and represents a clinical tool for an individualized approach to neurosensory restoration with cochlear implants.
format	article
author	M. Pietsch L. Aguirre Dávila P. Erfurt E. Avci T. Lenarz A. Kral
author_facet	M. Pietsch L. Aguirre Dávila P. Erfurt E. Avci T. Lenarz A. Kral
author_sort	M. Pietsch
title	Spiral Form of the Human Cochlea Results from Spatial Constraints
title_short	Spiral Form of the Human Cochlea Results from Spatial Constraints
title_full	Spiral Form of the Human Cochlea Results from Spatial Constraints
title_fullStr	Spiral Form of the Human Cochlea Results from Spatial Constraints
title_full_unstemmed	Spiral Form of the Human Cochlea Results from Spatial Constraints
title_sort	spiral form of the human cochlea results from spatial constraints
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/091231398d0f4c658b3c5b78c2ea14f2
work_keys_str_mv	AT mpietsch spiralformofthehumancochlearesultsfromspatialconstraints AT laguirredavila spiralformofthehumancochlearesultsfromspatialconstraints AT perfurt spiralformofthehumancochlearesultsfromspatialconstraints AT eavci spiralformofthehumancochlearesultsfromspatialconstraints AT tlenarz spiralformofthehumancochlearesultsfromspatialconstraints AT akral spiralformofthehumancochlearesultsfromspatialconstraints
_version_	1718384945032855552

Spiral Form of the Human Cochlea Results from Spatial Constraints

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