Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes

Abstract The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. We recently observed an enhanced upregulation of ACE by elevated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore i...

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Autores principales:	Rita Schüler, Martin A. Osterhoff, Turid Frahnow, Matthias Möhlig, Joachim Spranger, Darko Stefanovski, Richard N. Bergman, Li Xu, Anne-Cathrin Seltmann, Stefan Kabisch, Silke Hornemann, Michael Kruse, Andreas F. H. Pfeiffer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0913f2fc8a184fa1805fcb5bc6470a62
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spelling	oai:doaj.org-article:0913f2fc8a184fa1805fcb5bc6470a622021-12-02T12:32:38ZDietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes10.1038/s41598-017-08300-72045-2322https://doaj.org/article/0913f2fc8a184fa1805fcb5bc6470a622017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08300-7https://doaj.org/toc/2045-2322Abstract The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. We recently observed an enhanced upregulation of ACE by elevated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore investigated its potential nutrigenetic role in glucose metabolism. In this nutritional intervention study 46 healthy and non-obese twin pairs consumed recommended low fat diets for 6 weeks before they received a 6-week high fat (HF) diet under isocaloric conditions. Intravenous glucose tolerance tests were performed before and after 1 and 6 weeks of HF diet. While glucose tolerance did not differ between genotypes at baseline it significantly declined in GG-carriers after 6 weeks HF diet (p = 0.001) with higher 2 h glucose and insulin concentrations compared to AA/AG-carriers (p = 0.003 and p = 0.042). Furthermore, the gene-diet interaction was confirmed in the cross-sectional Metabolic Syndrome Berlin Potsdam study (p = 0.012), with the GG-genotypes being significantly associated with prevalent type 2 diabetes for participants with high dietary fat intake ≥37% (GG vs. AA/AG, OR 2.36 [1.02–5.49], p = 0.045). In conclusion, the association between the rs4343 variant and glucose tolerance is modulated by dietary fat intake. The ACE rs4343 variant is a novel nutrient-sensitive type 2 diabetes risk marker potentially applicable for nutrigenetic dietary counseling.Rita SchülerMartin A. OsterhoffTurid FrahnowMatthias MöhligJoachim SprangerDarko StefanovskiRichard N. BergmanLi XuAnne-Cathrin SeltmannStefan KabischSilke HornemannMichael KruseAndreas F. H. PfeifferNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rita Schüler Martin A. Osterhoff Turid Frahnow Matthias Möhlig Joachim Spranger Darko Stefanovski Richard N. Bergman Li Xu Anne-Cathrin Seltmann Stefan Kabisch Silke Hornemann Michael Kruse Andreas F. H. Pfeiffer Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
description	Abstract The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. We recently observed an enhanced upregulation of ACE by elevated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore investigated its potential nutrigenetic role in glucose metabolism. In this nutritional intervention study 46 healthy and non-obese twin pairs consumed recommended low fat diets for 6 weeks before they received a 6-week high fat (HF) diet under isocaloric conditions. Intravenous glucose tolerance tests were performed before and after 1 and 6 weeks of HF diet. While glucose tolerance did not differ between genotypes at baseline it significantly declined in GG-carriers after 6 weeks HF diet (p = 0.001) with higher 2 h glucose and insulin concentrations compared to AA/AG-carriers (p = 0.003 and p = 0.042). Furthermore, the gene-diet interaction was confirmed in the cross-sectional Metabolic Syndrome Berlin Potsdam study (p = 0.012), with the GG-genotypes being significantly associated with prevalent type 2 diabetes for participants with high dietary fat intake ≥37% (GG vs. AA/AG, OR 2.36 [1.02–5.49], p = 0.045). In conclusion, the association between the rs4343 variant and glucose tolerance is modulated by dietary fat intake. The ACE rs4343 variant is a novel nutrient-sensitive type 2 diabetes risk marker potentially applicable for nutrigenetic dietary counseling.
format	article
author	Rita Schüler Martin A. Osterhoff Turid Frahnow Matthias Möhlig Joachim Spranger Darko Stefanovski Richard N. Bergman Li Xu Anne-Cathrin Seltmann Stefan Kabisch Silke Hornemann Michael Kruse Andreas F. H. Pfeiffer
author_facet	Rita Schüler Martin A. Osterhoff Turid Frahnow Matthias Möhlig Joachim Spranger Darko Stefanovski Richard N. Bergman Li Xu Anne-Cathrin Seltmann Stefan Kabisch Silke Hornemann Michael Kruse Andreas F. H. Pfeiffer
author_sort	Rita Schüler
title	Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
title_short	Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
title_full	Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
title_fullStr	Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
title_full_unstemmed	Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes
title_sort	dietary fat intake modulates effects of a frequent ace gene variant on glucose tolerance with association to type 2 diabetes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/0913f2fc8a184fa1805fcb5bc6470a62
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Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes

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