Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes

Dietary Fat Intake Modulates Effects of a Frequent ACE Gene Variant on Glucose Tolerance with association to Type 2 Diabetes

Abstract The frequent ACE insertion/deletion polymorphism (I/D) is, albeit inconsistently, associated with impaired glucose tolerance and insulin resistance. We recently observed an enhanced upregulation of ACE by elevated fat intake in GG-carriers of the I/D-surrogate rs4343 variant and therefore i...

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Main Authors: Rita Schüler, Martin A. Osterhoff, Turid Frahnow, Matthias Möhlig, Joachim Spranger, Darko Stefanovski, Richard N. Bergman, Li Xu, Anne-Cathrin Seltmann, Stefan Kabisch, Silke Hornemann, Michael Kruse, Andreas F. H. Pfeiffer
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/0913f2fc8a184fa1805fcb5bc6470a62
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