Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy

Abstract Diabetic nephropathy (DN) is one of the major leading cause of kidney failure. To identify the progression of chronic kidney disease (CKD), renal function/fibrosis is playing a crucial role. Unfortunately, lack of sensitivities/specificities of available clinical biomarkers are key major is...

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Autores principales:	Chia-Hao Su, Yung-Chien Hsu, Suresh Thangudu, Wei-Yu Chen, Yu-Ting Huang, Chun-Chieh Yu, Ya-Hsueh Shih, Ching-Jen Wang, Chun-Liang Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09159f72cc7c482b95e3a185f9196410
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spelling	oai:doaj.org-article:09159f72cc7c482b95e3a185f91964102021-12-02T13:51:05ZApplication of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy10.1038/s41598-021-81519-72045-2322https://doaj.org/article/09159f72cc7c482b95e3a185f91964102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81519-7https://doaj.org/toc/2045-2322Abstract Diabetic nephropathy (DN) is one of the major leading cause of kidney failure. To identify the progression of chronic kidney disease (CKD), renal function/fibrosis is playing a crucial role. Unfortunately, lack of sensitivities/specificities of available clinical biomarkers are key major issues for practical healthcare applications to identify the renal functions/fibrosis in the early stage of DN. Thus, there is an emerging approach such as therapeutic or diagnostic are highly desired to conquer the CKD at earlier stages. Herein, we applied and examined the application of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and diffusion weighted imaging (DWI) to identify the progression of fibrosis between wild type (WT) and miR29a transgenic (Tg) mice during streptozotocin (STZ)-induced diabetes. Further, we also validate the potential renoprotective role of miR29a to maintain the renal perfusion, volume, and function. In addition, Ktrans values of DCE-MRI and apparent diffusion coefficient (ADC) of DWI could significantly reflect the level of fibrosis between WT and Tg mice at identical conditions. As a result, we strongly believed that the present non-invasive MR imaging platforms have potential to serveas an important tool in research and clinical imaging for renal fibrosis in diabetes, and that microenvironmental changes could be identified by MR imaging acquisition prior to histological biopsy and diabetic podocyte dysfunction.Chia-Hao SuYung-Chien HsuSuresh ThanguduWei-Yu ChenYu-Ting HuangChun-Chieh YuYa-Hsueh ShihChing-Jen WangChun-Liang LinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chia-Hao Su Yung-Chien Hsu Suresh Thangudu Wei-Yu Chen Yu-Ting Huang Chun-Chieh Yu Ya-Hsueh Shih Ching-Jen Wang Chun-Liang Lin Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy
description	Abstract Diabetic nephropathy (DN) is one of the major leading cause of kidney failure. To identify the progression of chronic kidney disease (CKD), renal function/fibrosis is playing a crucial role. Unfortunately, lack of sensitivities/specificities of available clinical biomarkers are key major issues for practical healthcare applications to identify the renal functions/fibrosis in the early stage of DN. Thus, there is an emerging approach such as therapeutic or diagnostic are highly desired to conquer the CKD at earlier stages. Herein, we applied and examined the application of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) and diffusion weighted imaging (DWI) to identify the progression of fibrosis between wild type (WT) and miR29a transgenic (Tg) mice during streptozotocin (STZ)-induced diabetes. Further, we also validate the potential renoprotective role of miR29a to maintain the renal perfusion, volume, and function. In addition, Ktrans values of DCE-MRI and apparent diffusion coefficient (ADC) of DWI could significantly reflect the level of fibrosis between WT and Tg mice at identical conditions. As a result, we strongly believed that the present non-invasive MR imaging platforms have potential to serveas an important tool in research and clinical imaging for renal fibrosis in diabetes, and that microenvironmental changes could be identified by MR imaging acquisition prior to histological biopsy and diabetic podocyte dysfunction.
format	article
author	Chia-Hao Su Yung-Chien Hsu Suresh Thangudu Wei-Yu Chen Yu-Ting Huang Chun-Chieh Yu Ya-Hsueh Shih Ching-Jen Wang Chun-Liang Lin
author_facet	Chia-Hao Su Yung-Chien Hsu Suresh Thangudu Wei-Yu Chen Yu-Ting Huang Chun-Chieh Yu Ya-Hsueh Shih Ching-Jen Wang Chun-Liang Lin
author_sort	Chia-Hao Su
title	Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy
title_short	Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy
title_full	Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy
title_fullStr	Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy
title_full_unstemmed	Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy
title_sort	application of multiparametric mr imaging to predict the diversification of renal function in mir29a-mediated diabetic nephropathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/09159f72cc7c482b95e3a185f9196410
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Application of multiparametric MR imaging to predict the diversification of renal function in miR29a-mediated diabetic nephropathy

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