Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent biologically active properties for biomedical applications,...

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Autores principales:	Cristina Mihaela Ghiciuc, Andrei Gheorghe Vicovan, Celina Silvia Stafie, Sabina Antonela Antoniu, Paraschiva Postolache
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	marine-derived compounds glucocorticoid-resistant severe asthma drug development biomedical applications Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/0917cc815806475a8a6144673059200d
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spelling	oai:doaj.org-article:0917cc815806475a8a6144673059200d2021-11-25T18:12:36ZMarine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma10.3390/md191105861660-3397https://doaj.org/article/0917cc815806475a8a6144673059200d2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/586https://doaj.org/toc/1660-3397One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent biologically active properties for biomedical applications, as well as their sustainability and safety for drug development. Based on the pathobiological features associated with glucocorticoid resistance in severe asthma, many studies have already described many glucocorticoid resistance mechanisms as potential therapeutic targets. On the other hand, in the last decade, many studies described the potentially anti-inflammatory effects of marine-derived biologically active compounds. Analyzing the underlying anti-inflammatory mechanisms of action for these marine-derived biologically active compounds, we observed some of the targeted pathogenic molecular mechanisms similar to those described in glucocorticoid (GC) resistant asthma. This article gathers the marine-derived compounds targeting pathogenic molecular mechanism involved in GC resistant asthma and provides a basis for the development of effective marine-derived drugs.Cristina Mihaela GhiciucAndrei Gheorghe VicovanCelina Silvia StafieSabina Antonela AntoniuParaschiva PostolacheMDPI AGarticlemarine-derived compoundsglucocorticoid-resistantsevere asthmadrug developmentbiomedical applicationsBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 586, p 586 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	marine-derived compounds glucocorticoid-resistant severe asthma drug development biomedical applications Biology (General) QH301-705.5
spellingShingle	marine-derived compounds glucocorticoid-resistant severe asthma drug development biomedical applications Biology (General) QH301-705.5 Cristina Mihaela Ghiciuc Andrei Gheorghe Vicovan Celina Silvia Stafie Sabina Antonela Antoniu Paraschiva Postolache Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
description	One of the challenges to the management of severe asthma is the poor therapeutic response to treatment with glucocorticosteroids. Compounds derived from marine sources have received increasing interest in recent years due to their prominent biologically active properties for biomedical applications, as well as their sustainability and safety for drug development. Based on the pathobiological features associated with glucocorticoid resistance in severe asthma, many studies have already described many glucocorticoid resistance mechanisms as potential therapeutic targets. On the other hand, in the last decade, many studies described the potentially anti-inflammatory effects of marine-derived biologically active compounds. Analyzing the underlying anti-inflammatory mechanisms of action for these marine-derived biologically active compounds, we observed some of the targeted pathogenic molecular mechanisms similar to those described in glucocorticoid (GC) resistant asthma. This article gathers the marine-derived compounds targeting pathogenic molecular mechanism involved in GC resistant asthma and provides a basis for the development of effective marine-derived drugs.
format	article
author	Cristina Mihaela Ghiciuc Andrei Gheorghe Vicovan Celina Silvia Stafie Sabina Antonela Antoniu Paraschiva Postolache
author_facet	Cristina Mihaela Ghiciuc Andrei Gheorghe Vicovan Celina Silvia Stafie Sabina Antonela Antoniu Paraschiva Postolache
author_sort	Cristina Mihaela Ghiciuc
title	Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
title_short	Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
title_full	Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
title_fullStr	Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
title_full_unstemmed	Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma
title_sort	marine-derived compounds for the potential treatment of glucocorticoid resistance in severe asthma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/0917cc815806475a8a6144673059200d
work_keys_str_mv	AT cristinamihaelaghiciuc marinederivedcompoundsforthepotentialtreatmentofglucocorticoidresistanceinsevereasthma AT andreigheorghevicovan marinederivedcompoundsforthepotentialtreatmentofglucocorticoidresistanceinsevereasthma AT celinasilviastafie marinederivedcompoundsforthepotentialtreatmentofglucocorticoidresistanceinsevereasthma AT sabinaantonelaantoniu marinederivedcompoundsforthepotentialtreatmentofglucocorticoidresistanceinsevereasthma AT paraschivapostolache marinederivedcompoundsforthepotentialtreatmentofglucocorticoidresistanceinsevereasthma
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Marine-Derived Compounds for the Potential Treatment of Glucocorticoid Resistance in Severe Asthma

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