ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis

Introduction: Conflicting evidences exist that ABO blood groups correlate with the susceptibility to COVID-19 and its clinical outcomes. This study aimed to pool available articles that assessed a possible relationship between COVID-19 and ABO blood groups. Materials and methods: A search was condu...

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Autores principales:	Richard Chinaza Ikeagwulonu, Chinonyelum Thecla Ezeonu, Mark Uchejeso Obeta, Ngozi Immaculata Ugwu, Nkereuwem Sunday Etukudoh, Henry Chukwuemeka Uro-Chukwu, Ifeyinwa Chizoba Akamike, Zeal Chinwe Ikeagwulonu
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:	abo blood group susceptibility severity mortality covid-19 sars-cov-2 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/0918de827fb64d41968d04008c596cf5
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spelling	oai:doaj.org-article:0918de827fb64d41968d04008c596cf52021-12-02T19:15:00ZABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis10.5281/zenodo.43441312695-5075https://doaj.org/article/0918de827fb64d41968d04008c596cf52020-12-01T00:00:00Zhttps://doi.org/10.5281/zenodo.4344131https://doaj.org/toc/2695-5075Introduction: Conflicting evidences exist that ABO blood groups correlate with the susceptibility to COVID-19 and its clinical outcomes. This study aimed to pool available articles that assessed a possible relationship between COVID-19 and ABO blood groups. Materials and methods: A search was conducted in four databases comprising Pubmed/Medline, Google scholar, Journal storage (JSTOR) and African Journals Online (AJOL) for relevant studies available before 25th August 2020 and contained extractable data on ABO blood type distribution and COVID-19 disease. Search terms included a combination of “ABO blood group, and COVID-19, coronavirus, and SARS-COV-2”. Results: Fourteen articles that met study inclusion criteria were selected from a total of five hundred and eighty-five articles identified through database search. The fourteen articles reviewed comprised of a total of 73934 subjects (13189 SARS-COV-2 positive cases and 60745 controls). Overall, the risk of SARS-COV-2 infection was found to be significantly increased in patients with blood group A with ORs: 1.24 (95%Cl: 1.09-1.41, P = 0.001). Additionally, blood group O subjects were seen to have decreased odds of contracting COVID-19 infection (OR: 0.78, 95%Cl: 0.68 – 0.89, P=0.0003). No significant association was found between ABO blood groups and COVID -19 severity and mortality. Conclusions: Blood group A was associated with a higher risk of SARS-COV-2 infection whereas risk of infection was lower in blood group O subjects. No statistical significant association was found between ABO blood groups and COVID-19 severity and mortality. The precise role of ABO blood group in COVID-19 susceptibility, severity and mortality requires further research for clarification.Richard Chinaza IkeagwulonuChinonyelum Thecla EzeonuMark Uchejeso ObetaNgozi Immaculata UgwuNkereuwem Sunday EtukudohHenry Chukwuemeka Uro-ChukwuIfeyinwa Chizoba AkamikeZeal Chinwe IkeagwulonuEmergency Department of Hospital San Pedro (Logroño, Spain)articleabo blood groupsusceptibilityseveritymortalitycovid-19sars-cov-2Medicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 3, Iss 1, Pp 71-84 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	abo blood group susceptibility severity mortality covid-19 sars-cov-2 Medicine (General) R5-920
spellingShingle	abo blood group susceptibility severity mortality covid-19 sars-cov-2 Medicine (General) R5-920 Richard Chinaza Ikeagwulonu Chinonyelum Thecla Ezeonu Mark Uchejeso Obeta Ngozi Immaculata Ugwu Nkereuwem Sunday Etukudoh Henry Chukwuemeka Uro-Chukwu Ifeyinwa Chizoba Akamike Zeal Chinwe Ikeagwulonu ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis
description	Introduction: Conflicting evidences exist that ABO blood groups correlate with the susceptibility to COVID-19 and its clinical outcomes. This study aimed to pool available articles that assessed a possible relationship between COVID-19 and ABO blood groups. Materials and methods: A search was conducted in four databases comprising Pubmed/Medline, Google scholar, Journal storage (JSTOR) and African Journals Online (AJOL) for relevant studies available before 25th August 2020 and contained extractable data on ABO blood type distribution and COVID-19 disease. Search terms included a combination of “ABO blood group, and COVID-19, coronavirus, and SARS-COV-2”. Results: Fourteen articles that met study inclusion criteria were selected from a total of five hundred and eighty-five articles identified through database search. The fourteen articles reviewed comprised of a total of 73934 subjects (13189 SARS-COV-2 positive cases and 60745 controls). Overall, the risk of SARS-COV-2 infection was found to be significantly increased in patients with blood group A with ORs: 1.24 (95%Cl: 1.09-1.41, P = 0.001). Additionally, blood group O subjects were seen to have decreased odds of contracting COVID-19 infection (OR: 0.78, 95%Cl: 0.68 – 0.89, P=0.0003). No significant association was found between ABO blood groups and COVID -19 severity and mortality. Conclusions: Blood group A was associated with a higher risk of SARS-COV-2 infection whereas risk of infection was lower in blood group O subjects. No statistical significant association was found between ABO blood groups and COVID-19 severity and mortality. The precise role of ABO blood group in COVID-19 susceptibility, severity and mortality requires further research for clarification.
format	article
author	Richard Chinaza Ikeagwulonu Chinonyelum Thecla Ezeonu Mark Uchejeso Obeta Ngozi Immaculata Ugwu Nkereuwem Sunday Etukudoh Henry Chukwuemeka Uro-Chukwu Ifeyinwa Chizoba Akamike Zeal Chinwe Ikeagwulonu
author_facet	Richard Chinaza Ikeagwulonu Chinonyelum Thecla Ezeonu Mark Uchejeso Obeta Ngozi Immaculata Ugwu Nkereuwem Sunday Etukudoh Henry Chukwuemeka Uro-Chukwu Ifeyinwa Chizoba Akamike Zeal Chinwe Ikeagwulonu
author_sort	Richard Chinaza Ikeagwulonu
title	ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis
title_short	ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis
title_full	ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis
title_fullStr	ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis
title_full_unstemmed	ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis
title_sort	abo blood group is associated with covid-19 susceptibility: a systematic review and meta-analysis
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2020
url	https://doaj.org/article/0918de827fb64d41968d04008c596cf5
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ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis

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