Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

Many alternative ORFs are co-encoded with characterized proteins, but their function is often not understood. Here, the authors discover that ribosomal protein L36 is co-encoded with alternative protein, which they identify as an upstream regulator of PI3K-AKT-mTOR signaling.

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Autores principales: Xiongwen Cao, Alexandra Khitun, Yang Luo, Zhenkun Na, Thitima Phoodokmai, Khomkrit Sappakhaw, Elizabeth Olatunji, Chayasith Uttamapinant, Sarah A. Slavoff
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/091905a115924482b3ee4fbf7e8b7e99
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spelling oai:doaj.org-article:091905a115924482b3ee4fbf7e8b7e992021-12-02T13:51:03ZAlt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM2410.1038/s41467-020-20841-62041-1723https://doaj.org/article/091905a115924482b3ee4fbf7e8b7e992021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20841-6https://doaj.org/toc/2041-1723Many alternative ORFs are co-encoded with characterized proteins, but their function is often not understood. Here, the authors discover that ribosomal protein L36 is co-encoded with alternative protein, which they identify as an upstream regulator of PI3K-AKT-mTOR signaling.Xiongwen CaoAlexandra KhitunYang LuoZhenkun NaThitima PhoodokmaiKhomkrit SappakhawElizabeth OlatunjiChayasith UttamapinantSarah A. SlavoffNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiongwen Cao
Alexandra Khitun
Yang Luo
Zhenkun Na
Thitima Phoodokmai
Khomkrit Sappakhaw
Elizabeth Olatunji
Chayasith Uttamapinant
Sarah A. Slavoff
Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
description Many alternative ORFs are co-encoded with characterized proteins, but their function is often not understood. Here, the authors discover that ribosomal protein L36 is co-encoded with alternative protein, which they identify as an upstream regulator of PI3K-AKT-mTOR signaling.
format article
author Xiongwen Cao
Alexandra Khitun
Yang Luo
Zhenkun Na
Thitima Phoodokmai
Khomkrit Sappakhaw
Elizabeth Olatunji
Chayasith Uttamapinant
Sarah A. Slavoff
author_facet Xiongwen Cao
Alexandra Khitun
Yang Luo
Zhenkun Na
Thitima Phoodokmai
Khomkrit Sappakhaw
Elizabeth Olatunji
Chayasith Uttamapinant
Sarah A. Slavoff
author_sort Xiongwen Cao
title Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
title_short Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
title_full Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
title_fullStr Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
title_full_unstemmed Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24
title_sort alt-rpl36 downregulates the pi3k-akt-mtor signaling pathway by interacting with tmem24
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/091905a115924482b3ee4fbf7e8b7e99
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