PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA

ApoE vector protein in association with apoB-100 directly transferring saturated and monounsaturated FA (SFA and MFA) in triglyceride form (composed of very low density lipoproteins (L)) to the cells which are assimilating FA by cooperative receptors of apoE. Only insulin dependent cells have apoe/B...

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Autores principales:	V. N. Titov, V. A. Amelyushkina, T. A. Rozhkova, M. Y. Kotlovskiy, A. V. Yakimenko, E. V. Kurdoyak, Y. V. Kotlovskiy, N. V. Aksyutina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2014
Materias:	hyperlipoproteinemia fatty acids apoe insulin dependent cells Science Q
Acceso en línea:	https://doaj.org/article/091b6abc565645b5a988982d9bc25547
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spelling	oai:doaj.org-article:091b6abc565645b5a988982d9bc255472021-11-23T06:14:30ZPARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA2541-94202587-9596https://doaj.org/article/091b6abc565645b5a988982d9bc255472014-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/1726https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596ApoE vector protein in association with apoB-100 directly transferring saturated and monounsaturated FA (SFA and MFA) in triglyceride form (composed of very low density lipoproteins (L)) to the cells which are assimilating FA by cooperative receptors of apoE. Only insulin dependent cells have apoe/B-l00 receptors on the cell membrane (skeletal myocytes, cardiac myocytes, periportal hepatocytes, adipocytes of subcutaneous fat and Kupffer's macrophages). Phylogenetically late apoE has a domain for protein-protein interaction unlike the other apos. Apo forms cooperative ligands: apoE/A-l, apoE/B-48 and apoE/B-100 while using this domain. At later stages of phylogenesis while apoE forms cooperative ligands it is also involved in cell transfer and absorption of polyunsatured essential fatty acids in high density L, SFA +MFA +unsatured FA in chylomicrons, SFA+MFA in very low density L. Phenotype E 33 appears to be regular. Phenotypes E2/2 and E4/4 are cause of hypertriglyceridemia of I and V types, which call destructive inflammation of arterial intima with atherothrombosis.V. N. TitovV. A. AmelyushkinaT. A. RozhkovaM. Y. KotlovskiyA. V. YakimenkoE. V. KurdoyakY. V. KotlovskiyN. V. AksyutinaScientific Сentre for Family Health and Human Reproduction Problemsarticlehyperlipoproteinemiafatty acidsapoeinsulin dependent cellsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 1, Pp 125-130 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hyperlipoproteinemia fatty acids apoe insulin dependent cells Science Q
spellingShingle	hyperlipoproteinemia fatty acids apoe insulin dependent cells Science Q V. N. Titov V. A. Amelyushkina T. A. Rozhkova M. Y. Kotlovskiy A. V. Yakimenko E. V. Kurdoyak Y. V. Kotlovskiy N. V. Aksyutina PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
description	ApoE vector protein in association with apoB-100 directly transferring saturated and monounsaturated FA (SFA and MFA) in triglyceride form (composed of very low density lipoproteins (L)) to the cells which are assimilating FA by cooperative receptors of apoE. Only insulin dependent cells have apoe/B-l00 receptors on the cell membrane (skeletal myocytes, cardiac myocytes, periportal hepatocytes, adipocytes of subcutaneous fat and Kupffer's macrophages). Phylogenetically late apoE has a domain for protein-protein interaction unlike the other apos. Apo forms cooperative ligands: apoE/A-l, apoE/B-48 and apoE/B-100 while using this domain. At later stages of phylogenesis while apoE forms cooperative ligands it is also involved in cell transfer and absorption of polyunsatured essential fatty acids in high density L, SFA +MFA +unsatured FA in chylomicrons, SFA+MFA in very low density L. Phenotype E 33 appears to be regular. Phenotypes E2/2 and E4/4 are cause of hypertriglyceridemia of I and V types, which call destructive inflammation of arterial intima with atherothrombosis.
format	article
author	V. N. Titov V. A. Amelyushkina T. A. Rozhkova M. Y. Kotlovskiy A. V. Yakimenko E. V. Kurdoyak Y. V. Kotlovskiy N. V. Aksyutina
author_facet	V. N. Titov V. A. Amelyushkina T. A. Rozhkova M. Y. Kotlovskiy A. V. Yakimenko E. V. Kurdoyak Y. V. Kotlovskiy N. V. Aksyutina
author_sort	V. N. Titov
title	PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
title_short	PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
title_full	PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
title_fullStr	PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
title_full_unstemmed	PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA
title_sort	participation of apolipoprotein e in transfer and absorption of fatty acids by the cells and causing of hyperlipoproteinemia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2014
url	https://doaj.org/article/091b6abc565645b5a988982d9bc25547
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PARTICIPATION OF APOLIPOPROTEIN E IN TRANSFER AND ABSORPTION OF FATTY ACIDS BY THE CELLS And CAUSING OF HYPERLIPOPROTEINEMIA

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