Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells

Abstract The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow th...

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Autores principales:	Pankaj Bharmoria, Meena Bisht, Maria C. Gomes, Margarida Martins, Márcia C. Neves, João F. Mano, Igor Bdikin, João A. P. Coutinho, Sónia P. M. Ventura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/091b78d2bf0d4836be044f6647df2f0f
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spelling	oai:doaj.org-article:091b78d2bf0d4836be044f6647df2f0f2021-12-02T16:55:24ZProtein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells10.1038/s41598-021-88482-32045-2322https://doaj.org/article/091b78d2bf0d4836be044f6647df2f0f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88482-3https://doaj.org/toc/2045-2322Abstract The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept.Pankaj BharmoriaMeena BishtMaria C. GomesMargarida MartinsMárcia C. NevesJoão F. ManoIgor BdikinJoão A. P. CoutinhoSónia P. M. VenturaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pankaj Bharmoria Meena Bisht Maria C. Gomes Margarida Martins Márcia C. Neves João F. Mano Igor Bdikin João A. P. Coutinho Sónia P. M. Ventura Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
description	Abstract The sustainable cellular delivery of the pleiotropic drug curcumin encounters drawbacks related to its fast autoxidation at the physiological pH, cytotoxicity of delivery vehicles and poor cellular uptake. A biomaterial compatible with curcumin and with the appropriate structure to allow the correct curcumin encapsulation considering its poor solubility in water, while maintaining its stability for a safe release was developed. In this work, the biomaterial developed started by the preparation of an oil-in-water nanoemulsion using with a cytocompatible copolymer (Pluronic F 127) coated with a positively charged protein (gelatin), designed as G-Cur-NE, to mitigate the cytotoxicity issue of curcumin. These G-Cur-NE showed excellent capacity to stabilize curcumin, to increase its bio-accessibility, while allowing to arrest its autoxidation during its successful application as an anticancer agent proved by the disintegration of MDA-MB-231 breast cancer cells as a proof of concept.
format	article
author	Pankaj Bharmoria Meena Bisht Maria C. Gomes Margarida Martins Márcia C. Neves João F. Mano Igor Bdikin João A. P. Coutinho Sónia P. M. Ventura
author_facet	Pankaj Bharmoria Meena Bisht Maria C. Gomes Margarida Martins Márcia C. Neves João F. Mano Igor Bdikin João A. P. Coutinho Sónia P. M. Ventura
author_sort	Pankaj Bharmoria
title	Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
title_short	Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
title_full	Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
title_fullStr	Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
title_full_unstemmed	Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells
title_sort	protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards mda-mb-231 cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/091b78d2bf0d4836be044f6647df2f0f
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Protein-olive oil-in-water nanoemulsions as encapsulation materials for curcumin acting as anticancer agent towards MDA-MB-231 cells

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