Artificial enamel induced by phase transformation of amorphous nanoparticles

Abstract Human tooth enamel has tightly packed c-axis-oriented hydroxyapatite (HAP: Ca10(PO4)6(OH)2) nanorods with high elastic modulus. Fabrication of an enamel architecture in vitro supports the repair of teeth using HAP; however, existing methods require complex and laborious steps to form an ena...

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Autores principales:	Kazuo Onuma, Mayumi Iijima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/091bd66025f24b0f8096bb1ab388dee7
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spelling	oai:doaj.org-article:091bd66025f24b0f8096bb1ab388dee72021-12-02T16:06:21ZArtificial enamel induced by phase transformation of amorphous nanoparticles10.1038/s41598-017-02949-w2045-2322https://doaj.org/article/091bd66025f24b0f8096bb1ab388dee72017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02949-whttps://doaj.org/toc/2045-2322Abstract Human tooth enamel has tightly packed c-axis-oriented hydroxyapatite (HAP: Ca10(PO4)6(OH)2) nanorods with high elastic modulus. Fabrication of an enamel architecture in vitro supports the repair of teeth using HAP; however, existing methods require complex and laborious steps to form an enamel-like structure. Here we present a very simple and effective technique for forming artificial enamel in near-physiological solution using a substrate composed of amorphous calcium phosphate (ACP) nanoparticles. Without any functionalized modification of the substrate surface, faint dissolution and successive phase transformation automatically induce formation of an intermediate layer of low-crystalline HAP nanoparticles, on which highly oriented HAP nanorods grow by geometrical selection. We also show that an enamel structure forms on a substrate of amorphous calcium carbonate when the surface nanoparticles react so as to form an intermediate layer similar to that in ACP. Our results demonstrate that there is a wide range of substrate choices for nanorod array formation. Contrary to current understanding, a stable surface designed in nanoscale is not essential for the growth of arranged guest crystals. Reactive amorphous nanoparticles and their transformation efficiently induce a nanorod array structure.Kazuo OnumaMayumi IijimaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuo Onuma Mayumi Iijima Artificial enamel induced by phase transformation of amorphous nanoparticles
description	Abstract Human tooth enamel has tightly packed c-axis-oriented hydroxyapatite (HAP: Ca10(PO4)6(OH)2) nanorods with high elastic modulus. Fabrication of an enamel architecture in vitro supports the repair of teeth using HAP; however, existing methods require complex and laborious steps to form an enamel-like structure. Here we present a very simple and effective technique for forming artificial enamel in near-physiological solution using a substrate composed of amorphous calcium phosphate (ACP) nanoparticles. Without any functionalized modification of the substrate surface, faint dissolution and successive phase transformation automatically induce formation of an intermediate layer of low-crystalline HAP nanoparticles, on which highly oriented HAP nanorods grow by geometrical selection. We also show that an enamel structure forms on a substrate of amorphous calcium carbonate when the surface nanoparticles react so as to form an intermediate layer similar to that in ACP. Our results demonstrate that there is a wide range of substrate choices for nanorod array formation. Contrary to current understanding, a stable surface designed in nanoscale is not essential for the growth of arranged guest crystals. Reactive amorphous nanoparticles and their transformation efficiently induce a nanorod array structure.
format	article
author	Kazuo Onuma Mayumi Iijima
author_facet	Kazuo Onuma Mayumi Iijima
author_sort	Kazuo Onuma
title	Artificial enamel induced by phase transformation of amorphous nanoparticles
title_short	Artificial enamel induced by phase transformation of amorphous nanoparticles
title_full	Artificial enamel induced by phase transformation of amorphous nanoparticles
title_fullStr	Artificial enamel induced by phase transformation of amorphous nanoparticles
title_full_unstemmed	Artificial enamel induced by phase transformation of amorphous nanoparticles
title_sort	artificial enamel induced by phase transformation of amorphous nanoparticles
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/091bd66025f24b0f8096bb1ab388dee7
work_keys_str_mv	AT kazuoonuma artificialenamelinducedbyphasetransformationofamorphousnanoparticles AT mayumiiijima artificialenamelinducedbyphasetransformationofamorphousnanoparticles
_version_	1718385005885915136

Artificial enamel induced by phase transformation of amorphous nanoparticles

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