Adhesion of osteoblasts to a nanorough titanium implant surface

Ekaterina Gongadze1, Doron Kabaso2, Sebastian Bauer3, Tomaž Slivnik2, Patrik Schmuki3, Ursula van Rienen1, Ale&scaron; Iglič21Institute of General Electrical Engineering, University of Rostock, Rostock, Germany; 2Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljub...

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Autores principales:	Gongadze E, Kabaso DD, Bauer S, Slivnik T, Schmuki PP, van Rienen U, Iglič A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/091ea0e6208b4d609bfe71f4be9c77f7
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spelling	oai:doaj.org-article:091ea0e6208b4d609bfe71f4be9c77f72021-12-02T05:02:52ZAdhesion of osteoblasts to a nanorough titanium implant surface1176-91141178-2013https://doaj.org/article/091ea0e6208b4d609bfe71f4be9c77f72011-08-01T00:00:00Zhttp://www.dovepress.com/adhesion-of-osteoblasts-to-a-nanorough-titanium-implant-surface-a8187https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Ekaterina Gongadze1, Doron Kabaso2, Sebastian Bauer3, Tomaž Slivnik2, Patrik Schmuki3, Ursula van Rienen1, Ale&scaron; Iglič21Institute of General Electrical Engineering, University of Rostock, Rostock, Germany; 2Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia; 3Department of Materials Science, Friedrich-Alexander University of Erlangen-Nurenberg, Erlangen, GermanyAbstract: This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.Keywords: osteoblasts, nanostructures, adhesion, titanium implants, osteointegrationGongadze EKabaso DDBauer SSlivnik TSchmuki PPvan Rienen UIglič ADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1801-1816 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Gongadze E Kabaso DD Bauer S Slivnik T Schmuki PP van Rienen U Iglič A Adhesion of osteoblasts to a nanorough titanium implant surface
description	Ekaterina Gongadze1, Doron Kabaso2, Sebastian Bauer3, Tomaž Slivnik2, Patrik Schmuki3, Ursula van Rienen1, Ale&scaron; Iglič21Institute of General Electrical Engineering, University of Rostock, Rostock, Germany; 2Laboratory of Biophysics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia; 3Department of Materials Science, Friedrich-Alexander University of Erlangen-Nurenberg, Erlangen, GermanyAbstract: This work considers the adhesion of cells to a nanorough titanium implant surface with sharp edges. The basic assumption was that the attraction between the negatively charged titanium surface and a negatively charged osteoblast is mediated by charged proteins with a distinctive quadrupolar internal charge distribution. Similarly, cation-mediated attraction between fibronectin molecules and the titanium surface is expected to be more efficient for a high surface charge density, resulting in facilitated integrin mediated osteoblast adhesion. We suggest that osteoblasts are most strongly bound along the sharp convex edges or spikes of nanorough titanium surfaces where the magnitude of the negative surface charge density is the highest. It is therefore plausible that nanorough regions of titanium surfaces with sharp edges and spikes promote the adhesion of osteoblasts.Keywords: osteoblasts, nanostructures, adhesion, titanium implants, osteointegration
format	article
author	Gongadze E Kabaso DD Bauer S Slivnik T Schmuki PP van Rienen U Iglič A
author_facet	Gongadze E Kabaso DD Bauer S Slivnik T Schmuki PP van Rienen U Iglič A
author_sort	Gongadze E
title	Adhesion of osteoblasts to a nanorough titanium implant surface
title_short	Adhesion of osteoblasts to a nanorough titanium implant surface
title_full	Adhesion of osteoblasts to a nanorough titanium implant surface
title_fullStr	Adhesion of osteoblasts to a nanorough titanium implant surface
title_full_unstemmed	Adhesion of osteoblasts to a nanorough titanium implant surface
title_sort	adhesion of osteoblasts to a nanorough titanium implant surface
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/091ea0e6208b4d609bfe71f4be9c77f7
work_keys_str_mv	AT gongadzee adhesionofosteoblaststoananoroughtitaniumimplantsurface AT kabasodd adhesionofosteoblaststoananoroughtitaniumimplantsurface AT bauers adhesionofosteoblaststoananoroughtitaniumimplantsurface AT slivnikt adhesionofosteoblaststoananoroughtitaniumimplantsurface AT schmukipp adhesionofosteoblaststoananoroughtitaniumimplantsurface AT vanrienenu adhesionofosteoblaststoananoroughtitaniumimplantsurface AT iglica adhesionofosteoblaststoananoroughtitaniumimplantsurface
_version_	1718400691605602304

Adhesion of osteoblasts to a nanorough titanium implant surface

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