Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells mainly by the angiotensin converting enzyme 2 (ACE2) receptor, which can recognize the spike (S) protein by its extracellular domain. Previously, recombinant soluble ACE2 (sACE2) has been clinically used as a therapeu...

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Autores principales:	Fengling Feng, Jiaoshan Chen, Jin Zhao, Yanjun Li, Minchao Li, Caijun Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 ACE2 receptor soluble ACE2 optimized sACE2 therapeutic agent Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/092053f60eb24fc79b2cfaf504077729
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spelling	oai:doaj.org-article:092053f60eb24fc79b2cfaf5040777292021-11-25T19:13:42ZKilling Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection10.3390/v131122431999-4915https://doaj.org/article/092053f60eb24fc79b2cfaf5040777292021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2243https://doaj.org/toc/1999-4915The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells mainly by the angiotensin converting enzyme 2 (ACE2) receptor, which can recognize the spike (S) protein by its extracellular domain. Previously, recombinant soluble ACE2 (sACE2) has been clinically used as a therapeutic treatment for cardiovascular diseases. Recent data demonstrated that sACE2 can also be exploited as a decoy to effectively inhibit the cell entry of SARS-CoV-2, through blocking SARS-CoV-2 binding to membrane-anchored ACE2. In this study, we summarized the current findings on the optimized sACE2-based strategies as a therapeutic agent, including Fc fusion to prolong the half-life of sACE2, deep mutagenesis to create high-affinity decoys for SARS-CoV-2, or designing the truncated functional fragments to enhance its safety, among others. Considering that COVID-19 patients are often accompanied by manifestations of cardiovascular complications, we think that administration of sACE2 in COVID-19 patients may be a promising therapeutic strategy to simultaneously treat both cardiovascular diseases and SARS-CoV-2 infection. This review would provide insights for the development of novel therapeutic agents against the COVID-19 pandemic.Fengling FengJiaoshan ChenJin ZhaoYanjun LiMinchao LiCaijun SunMDPI AGarticleSARS-CoV-2ACE2 receptorsoluble ACE2optimized sACE2therapeutic agentMicrobiologyQR1-502ENViruses, Vol 13, Iss 2243, p 2243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 ACE2 receptor soluble ACE2 optimized sACE2 therapeutic agent Microbiology QR1-502
spellingShingle	SARS-CoV-2 ACE2 receptor soluble ACE2 optimized sACE2 therapeutic agent Microbiology QR1-502 Fengling Feng Jiaoshan Chen Jin Zhao Yanjun Li Minchao Li Caijun Sun Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection
description	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters host cells mainly by the angiotensin converting enzyme 2 (ACE2) receptor, which can recognize the spike (S) protein by its extracellular domain. Previously, recombinant soluble ACE2 (sACE2) has been clinically used as a therapeutic treatment for cardiovascular diseases. Recent data demonstrated that sACE2 can also be exploited as a decoy to effectively inhibit the cell entry of SARS-CoV-2, through blocking SARS-CoV-2 binding to membrane-anchored ACE2. In this study, we summarized the current findings on the optimized sACE2-based strategies as a therapeutic agent, including Fc fusion to prolong the half-life of sACE2, deep mutagenesis to create high-affinity decoys for SARS-CoV-2, or designing the truncated functional fragments to enhance its safety, among others. Considering that COVID-19 patients are often accompanied by manifestations of cardiovascular complications, we think that administration of sACE2 in COVID-19 patients may be a promising therapeutic strategy to simultaneously treat both cardiovascular diseases and SARS-CoV-2 infection. This review would provide insights for the development of novel therapeutic agents against the COVID-19 pandemic.
format	article
author	Fengling Feng Jiaoshan Chen Jin Zhao Yanjun Li Minchao Li Caijun Sun
author_facet	Fengling Feng Jiaoshan Chen Jin Zhao Yanjun Li Minchao Li Caijun Sun
author_sort	Fengling Feng
title	Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection
title_short	Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection
title_full	Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection
title_fullStr	Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection
title_full_unstemmed	Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection
title_sort	killing two birds with one stone by administration of soluble ace2: a promising strategy to treat both cardiovascular diseases and sars-cov-2 infection
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/092053f60eb24fc79b2cfaf504077729
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Killing Two Birds with One Stone by Administration of Soluble ACE2: A Promising Strategy to Treat Both Cardiovascular Diseases and SARS-CoV-2 Infection

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