Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures

Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures

Abstract The aim of this study was to investigate the presence of preoperative DVT following spinal fracture and the association between the presence of DVT and risk factors. Ultrasonography and blood analyses were performed preoperatively in patients diagnosed with spinal fracture between October 2...

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Autores principales: Jiangtao Ma, Pei Du, Jin Qin, Yali Zhou, Ningxi Liang, Jinglve Hu, Yingze Zhang, Yanbin Zhu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/0921e07491b348c1851c7e7e9d03f171
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spelling oai:doaj.org-article:0921e07491b348c1851c7e7e9d03f1712021-12-02T14:16:57ZIncidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures10.1038/s41598-021-82147-x2045-2322https://doaj.org/article/0921e07491b348c1851c7e7e9d03f1712021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82147-xhttps://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the presence of preoperative DVT following spinal fracture and the association between the presence of DVT and risk factors. Ultrasonography and blood analyses were performed preoperatively in patients diagnosed with spinal fracture between October 2014 and December 2018. Univariate analyses were performed on the data of demographics, comorbidities, location of injury, spinal cord injury (SCI) grading and laboratory biomarkers. The receiver operating characteristic (ROC) curve analysis was employed to obtain the optimal D-dimer cut-off value for diagnosis. In total, 2432 patients with spinal fractures were included, among whom 108 (4.4%) patients had preoperative DVTs. The average interval between fracture and initial diagnosis of DVT was 4.7 days (median, 2 days), ranging from 0 to 20 days; 78 (72.2%) were diagnosed within 7 days after injury and 67 (62.0%) within 3 days; 19 (17.5%) patients had proximal vein involved and 89 (82.4%) presented in distal veins. Multivariate logistic regression suggested six risk factors independently correlated to DVT, including delay to DUS (in each day) (odds ratio [OR] = 1.11), ASA class III–IV (OR = 2.36), ASIA grade (A/B) (OR = 2.36), ALB < 3.5 g/dL (OR = 2.08), HDL-C < 1.1 mmol/L (OR = 1.68) and d-Dimer > 1.08 µg/ml (OR = 2.49).Jiangtao MaPei DuJin QinYali ZhouNingxi LiangJinglve HuYingze ZhangYanbin ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Jiangtao Ma
Pei Du
Jin Qin
Yali Zhou
Ningxi Liang
Jinglve Hu
Yingze Zhang
Yanbin Zhu
Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
description Abstract The aim of this study was to investigate the presence of preoperative DVT following spinal fracture and the association between the presence of DVT and risk factors. Ultrasonography and blood analyses were performed preoperatively in patients diagnosed with spinal fracture between October 2014 and December 2018. Univariate analyses were performed on the data of demographics, comorbidities, location of injury, spinal cord injury (SCI) grading and laboratory biomarkers. The receiver operating characteristic (ROC) curve analysis was employed to obtain the optimal D-dimer cut-off value for diagnosis. In total, 2432 patients with spinal fractures were included, among whom 108 (4.4%) patients had preoperative DVTs. The average interval between fracture and initial diagnosis of DVT was 4.7 days (median, 2 days), ranging from 0 to 20 days; 78 (72.2%) were diagnosed within 7 days after injury and 67 (62.0%) within 3 days; 19 (17.5%) patients had proximal vein involved and 89 (82.4%) presented in distal veins. Multivariate logistic regression suggested six risk factors independently correlated to DVT, including delay to DUS (in each day) (odds ratio [OR] = 1.11), ASA class III–IV (OR = 2.36), ASIA grade (A/B) (OR = 2.36), ALB < 3.5 g/dL (OR = 2.08), HDL-C < 1.1 mmol/L (OR = 1.68) and d-Dimer > 1.08 µg/ml (OR = 2.49).
format article
author Jiangtao Ma
Pei Du
Jin Qin
Yali Zhou
Ningxi Liang
Jinglve Hu
Yingze Zhang
Yanbin Zhu
author_facet Jiangtao Ma
Pei Du
Jin Qin
Yali Zhou
Ningxi Liang
Jinglve Hu
Yingze Zhang
Yanbin Zhu
author_sort Jiangtao Ma
title Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
title_short Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
title_full Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
title_fullStr Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
title_full_unstemmed Incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
title_sort incidence and risk factors predicting deep venous thrombosis of lower extremity following spinal fractures
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/0921e07491b348c1851c7e7e9d03f171
work_keys_str_mv AT jiangtaoma incidenceandriskfactorspredictingdeepvenousthrombosisoflowerextremityfollowingspinalfractures
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