Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice

Abstract The gut microbiota has tremendous potential to affect the host’s health, in part by synthesizing vitamins and generating nutrients from food that is otherwise indigestible by the host. 1,5-Anhydro-d-fructose (1,5-AF) is a monosaccharide with a wide range of bioactive potentials, including a...

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Autores principales:	Takashi Ito, Takaaki Totoki, Seiya Takada, Shotaro Otsuka, Ikuro Maruyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/092798094f4d4f168e83758f5e9d5e42
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spelling	oai:doaj.org-article:092798094f4d4f168e83758f5e9d5e422021-12-02T18:01:40ZPotential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice10.1038/s41598-021-99052-y2045-2322https://doaj.org/article/092798094f4d4f168e83758f5e9d5e422021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99052-yhttps://doaj.org/toc/2045-2322Abstract The gut microbiota has tremendous potential to affect the host’s health, in part by synthesizing vitamins and generating nutrients from food that is otherwise indigestible by the host. 1,5-Anhydro-d-fructose (1,5-AF) is a monosaccharide with a wide range of bioactive potentials, including anti-oxidant, anti-inflammatory, and anti-microbial effects. Based on its potential benefits and minimal toxicity, it is anticipated that 1,5-AF will be used as a dietary supplement to support general health. However, the effects of 1,5-AF on the gut microbiota are yet to be clarified. Here, using an unbiased metagenomic approach, we profiled the bacterial taxa and functional genes in the caecal microbiota of mice fed a diet containing either 2% 1,5-AF or a reference sweetener. Supplementation with 1,5-AF altered the composition of the gut microbiota, enriching the proportion of Faecalibacterium prausnitzii. 1,5-AF also altered the metabolomic profile of the gut microbiota, enriching genes associated with nicotinamide adenine dinucleotide biosynthesis. These findings support the potential benefits of 1,5-AF, but further studies are required to clarify the impact of 1,5-AF on health and disease.Takashi ItoTakaaki TotokiSeiya TakadaShotaro OtsukaIkuro MaruyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takashi Ito Takaaki Totoki Seiya Takada Shotaro Otsuka Ikuro Maruyama Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
description	Abstract The gut microbiota has tremendous potential to affect the host’s health, in part by synthesizing vitamins and generating nutrients from food that is otherwise indigestible by the host. 1,5-Anhydro-d-fructose (1,5-AF) is a monosaccharide with a wide range of bioactive potentials, including anti-oxidant, anti-inflammatory, and anti-microbial effects. Based on its potential benefits and minimal toxicity, it is anticipated that 1,5-AF will be used as a dietary supplement to support general health. However, the effects of 1,5-AF on the gut microbiota are yet to be clarified. Here, using an unbiased metagenomic approach, we profiled the bacterial taxa and functional genes in the caecal microbiota of mice fed a diet containing either 2% 1,5-AF or a reference sweetener. Supplementation with 1,5-AF altered the composition of the gut microbiota, enriching the proportion of Faecalibacterium prausnitzii. 1,5-AF also altered the metabolomic profile of the gut microbiota, enriching genes associated with nicotinamide adenine dinucleotide biosynthesis. These findings support the potential benefits of 1,5-AF, but further studies are required to clarify the impact of 1,5-AF on health and disease.
format	article
author	Takashi Ito Takaaki Totoki Seiya Takada Shotaro Otsuka Ikuro Maruyama
author_facet	Takashi Ito Takaaki Totoki Seiya Takada Shotaro Otsuka Ikuro Maruyama
author_sort	Takashi Ito
title	Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
title_short	Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
title_full	Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
title_fullStr	Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
title_full_unstemmed	Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
title_sort	potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/092798094f4d4f168e83758f5e9d5e42
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Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice

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