EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.

<h4>Introduction</h4>The new, five-level EQ-5D generic questionnaire (EQ-5D-5L) has never been used among diabetes patients in Poland.<h4>Objectives</h4>To develop health-related quality of life (HRQoL) norms for patients with self-reported diabetes, based on a large represen...

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Autores principales:	Agnieszka Jankowska, Dominik Golicki
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09289b7472934f1895d2ca1597cc2274
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spelling	oai:doaj.org-article:09289b7472934f1895d2ca1597cc22742021-12-02T20:14:00ZEQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.1932-620310.1371/journal.pone.0257998https://doaj.org/article/09289b7472934f1895d2ca1597cc22742021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257998https://doaj.org/toc/1932-6203<h4>Introduction</h4>The new, five-level EQ-5D generic questionnaire (EQ-5D-5L) has never been used among diabetes patients in Poland.<h4>Objectives</h4>To develop health-related quality of life (HRQoL) norms for patients with self-reported diabetes, based on a large representative sample of the general Polish population, using the EQ-5D-5L.<h4>Materials and methods</h4>Members of the general public, selected via multistage stratified sampling, filled in the EQ-5D-5L questionnaire and answered a question about the presence of diabetes. We estimated three types of EQ-5D-5L outcomes: limitations within domains, EQ VAS and EQ-5D-5L index. Multiple linear regression was used to examine the relationship between sociodemographic characteristics and HRQoL, both in patients with diabetes and the general population sample.<h4>Results</h4>Among 2,973 respondents having complete EQ-5D-5L data, 255 subjects (8.6%) self-reported diabetes. Treatment with insulin, other drugs, combination therapy or lack of drug treatment was declared by 22.0%, 48.6%, 5.1% and 24.3% of patients, respectively. Respondents with diabetes had a lower EQ VAS score (18.5 points difference on a 100-points scale) and a lower EQ-5D-5L index score (0.135 difference; scale range: 1.59). The multivariate analysis showed that the factors independently improving the HRQoL in the general population were secondary or higher education, and factors reducing HRQoL were female sex, belonging to an older age group, being treated because of diabetes with insulin, other drugs or combination treatment. Respondents diagnosed with diabetes but not treated with drugs showed a decrease in EQ VAS scores, but not in the EQ-5D-5L index.<h4>Conclusions</h4>Diabetes leads to HRQoL deterioration in all age groups when compared to matched general population respondents without diabetes. The most significant HRQoL reduction experience older patients with a basic level of education. Obtained EQ-5D-5L normative data may be used in the clinical care of patients with diabetes and health technology assessment of new anti-diabetic drugs.Agnieszka JankowskaDominik GolickiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257998 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Agnieszka Jankowska Dominik Golicki EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.
description	<h4>Introduction</h4>The new, five-level EQ-5D generic questionnaire (EQ-5D-5L) has never been used among diabetes patients in Poland.<h4>Objectives</h4>To develop health-related quality of life (HRQoL) norms for patients with self-reported diabetes, based on a large representative sample of the general Polish population, using the EQ-5D-5L.<h4>Materials and methods</h4>Members of the general public, selected via multistage stratified sampling, filled in the EQ-5D-5L questionnaire and answered a question about the presence of diabetes. We estimated three types of EQ-5D-5L outcomes: limitations within domains, EQ VAS and EQ-5D-5L index. Multiple linear regression was used to examine the relationship between sociodemographic characteristics and HRQoL, both in patients with diabetes and the general population sample.<h4>Results</h4>Among 2,973 respondents having complete EQ-5D-5L data, 255 subjects (8.6%) self-reported diabetes. Treatment with insulin, other drugs, combination therapy or lack of drug treatment was declared by 22.0%, 48.6%, 5.1% and 24.3% of patients, respectively. Respondents with diabetes had a lower EQ VAS score (18.5 points difference on a 100-points scale) and a lower EQ-5D-5L index score (0.135 difference; scale range: 1.59). The multivariate analysis showed that the factors independently improving the HRQoL in the general population were secondary or higher education, and factors reducing HRQoL were female sex, belonging to an older age group, being treated because of diabetes with insulin, other drugs or combination treatment. Respondents diagnosed with diabetes but not treated with drugs showed a decrease in EQ VAS scores, but not in the EQ-5D-5L index.<h4>Conclusions</h4>Diabetes leads to HRQoL deterioration in all age groups when compared to matched general population respondents without diabetes. The most significant HRQoL reduction experience older patients with a basic level of education. Obtained EQ-5D-5L normative data may be used in the clinical care of patients with diabetes and health technology assessment of new anti-diabetic drugs.
format	article
author	Agnieszka Jankowska Dominik Golicki
author_facet	Agnieszka Jankowska Dominik Golicki
author_sort	Agnieszka Jankowska
title	EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.
title_short	EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.
title_full	EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.
title_fullStr	EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.
title_full_unstemmed	EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.
title_sort	eq-5d-5l-based quality of life normative data for patients with self-reported diabetes in poland.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/09289b7472934f1895d2ca1597cc2274
work_keys_str_mv	AT agnieszkajankowska eq5d5lbasedqualityoflifenormativedataforpatientswithselfreporteddiabetesinpoland AT dominikgolicki eq5d5lbasedqualityoflifenormativedataforpatientswithselfreporteddiabetesinpoland
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EQ-5D-5L-based quality of life normative data for patients with self-reported diabetes in Poland.

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