Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial

Abstract Probiotic use may be an efficacious treatment option to effectively manage symptoms of prenatal maternal anxiety and depression. Our primary aim was to test feasibility and acceptability for a probiotic randomized controlled trial (RCT) in pregnant women with pre-existing symptoms. This dou...

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Autores principales:	Pamela D. Browne, Antoinette C. Bolte, Isolde Besseling-van der Vaart, Eric Claassen, Carolina de Weerth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0928b6a0ef9b4d91bb98eae1136efdd2
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spelling	oai:doaj.org-article:0928b6a0ef9b4d91bb98eae1136efdd22021-12-02T14:06:57ZProbiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial10.1038/s41598-021-81204-92045-2322https://doaj.org/article/0928b6a0ef9b4d91bb98eae1136efdd22021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81204-9https://doaj.org/toc/2045-2322Abstract Probiotic use may be an efficacious treatment option to effectively manage symptoms of prenatal maternal anxiety and depression. Our primary aim was to test feasibility and acceptability for a probiotic randomized controlled trial (RCT) in pregnant women with pre-existing symptoms. This double-blind pilot RCT included 40 pregnant women with low-risk pregnancies and elevated depressive symptoms and/or anxiety. Once daily, participants orally consumed a probiotic (Ecologic Barrier) or a placebo, from 26 to 30 weeks gestation until delivery. A priori key progression criteria for primary outcomes were determined to decide whether or not a full RCT was feasible and acceptable. Secondary outcomes included depressive symptoms, anxiety, stress, and maternal bonding to offspring. In 19 months, 1573 women were screened; following screening, 155 women (10%) were invited for participation, of whom 135 (87%) received study information, and 40 women (30%) were included. Four out of six a priori determined criteria for success on feasibility and acceptability were met. After 8 weeks of intervention, there was no significant difference between the probiotic and placebo groups for secondary outcomes. The pilot trial was feasible and acceptable, but hampered by recruitment method and study design. Secondary endpoints did not reveal differences between the groups for improving maternal mood.Pamela D. BrowneAntoinette C. BolteIsolde Besseling-van der VaartEric ClaassenCarolina de WeerthNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pamela D. Browne Antoinette C. Bolte Isolde Besseling-van der Vaart Eric Claassen Carolina de Weerth Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
description	Abstract Probiotic use may be an efficacious treatment option to effectively manage symptoms of prenatal maternal anxiety and depression. Our primary aim was to test feasibility and acceptability for a probiotic randomized controlled trial (RCT) in pregnant women with pre-existing symptoms. This double-blind pilot RCT included 40 pregnant women with low-risk pregnancies and elevated depressive symptoms and/or anxiety. Once daily, participants orally consumed a probiotic (Ecologic Barrier) or a placebo, from 26 to 30 weeks gestation until delivery. A priori key progression criteria for primary outcomes were determined to decide whether or not a full RCT was feasible and acceptable. Secondary outcomes included depressive symptoms, anxiety, stress, and maternal bonding to offspring. In 19 months, 1573 women were screened; following screening, 155 women (10%) were invited for participation, of whom 135 (87%) received study information, and 40 women (30%) were included. Four out of six a priori determined criteria for success on feasibility and acceptability were met. After 8 weeks of intervention, there was no significant difference between the probiotic and placebo groups for secondary outcomes. The pilot trial was feasible and acceptable, but hampered by recruitment method and study design. Secondary endpoints did not reveal differences between the groups for improving maternal mood.
format	article
author	Pamela D. Browne Antoinette C. Bolte Isolde Besseling-van der Vaart Eric Claassen Carolina de Weerth
author_facet	Pamela D. Browne Antoinette C. Bolte Isolde Besseling-van der Vaart Eric Claassen Carolina de Weerth
author_sort	Pamela D. Browne
title	Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
title_short	Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
title_full	Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
title_fullStr	Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
title_full_unstemmed	Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
title_sort	probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0928b6a0ef9b4d91bb98eae1136efdd2
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Probiotics as a treatment for prenatal maternal anxiety and depression: a double-blind randomized pilot trial

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