Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity

Yeon Kyung Lee,1,* Eun-Ju Choi,2,* Thomas J Webster,3 Sang-Hyun Kim,4 Dongwoo Khang1 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea; 2Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea; 3Department...

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Autores principales: Lee YK, Choi EJ, Webster TJ, Kim SH, Khang D
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
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Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/0928e9523da046d5934c46ccb0114a6a
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spelling oai:doaj.org-article:0928e9523da046d5934c46ccb0114a6a2021-12-02T04:28:17ZEffect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity1178-2013https://doaj.org/article/0928e9523da046d5934c46ccb0114a6a2014-12-01T00:00:00Zhttp://www.dovepress.com/effect-of-the-protein-corona-on-nanoparticles-fornbspmodulating-cytoto-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Yeon Kyung Lee,1,* Eun-Ju Choi,2,* Thomas J Webster,3 Sang-Hyun Kim,4 Dongwoo Khang1 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea; 2Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea; 3Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 4Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses. Keywords: nanostructured biomaterials, blood response, cytotoxicity, immunotoxicity, protein coronaLee YKChoi EJWebster TJKim SHKhang DDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 97-113 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Lee YK
Choi EJ
Webster TJ
Kim SH
Khang D
Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
description Yeon Kyung Lee,1,* Eun-Ju Choi,2,* Thomas J Webster,3 Sang-Hyun Kim,4 Dongwoo Khang1 1Department of Molecular Medicine, School of Medicine, Gachon University, Incheon, South Korea; 2Division of Sport Science, College of Science and Technology, Konkuk University, Chungju, South Korea; 3Department of Chemical Engineering and Program in Bioengineering, Northeastern University, Boston, MA, USA; 4Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: Although the cytotoxicity of nanoparticles (NPs) is greatly influenced by their interactions with blood proteins, toxic effects resulting from blood interactions are often ignored in the development and use of nanostructured biomaterials for in vivo applications. Protein coronas created during the initial reaction with NPs can determine the subsequent immunological cascade, and protein coronas formed on NPs can either stimulate or mitigate the immune response. Along these lines, the understanding of NP-protein corona formation in terms of physiochemical surface properties of the NPs and NP interactions with the immune system components in blood is an essential step for evaluating NP toxicity for in vivo therapeutics. This article reviews the most recent developments in NP-based protein coronas through the modification of NP surface properties and discusses the associated immune responses. Keywords: nanostructured biomaterials, blood response, cytotoxicity, immunotoxicity, protein corona
format article
author Lee YK
Choi EJ
Webster TJ
Kim SH
Khang D
author_facet Lee YK
Choi EJ
Webster TJ
Kim SH
Khang D
author_sort Lee YK
title Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
title_short Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
title_full Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
title_fullStr Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
title_full_unstemmed Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
title_sort effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/0928e9523da046d5934c46ccb0114a6a
work_keys_str_mv AT leeyk effectoftheproteincoronaonnanoparticlesfornbspmodulatingcytotoxicityandimmunotoxicity
AT choiej effectoftheproteincoronaonnanoparticlesfornbspmodulatingcytotoxicityandimmunotoxicity
AT webstertj effectoftheproteincoronaonnanoparticlesfornbspmodulatingcytotoxicityandimmunotoxicity
AT kimsh effectoftheproteincoronaonnanoparticlesfornbspmodulatingcytotoxicityandimmunotoxicity
AT khangd effectoftheproteincoronaonnanoparticlesfornbspmodulatingcytotoxicityandimmunotoxicity
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