Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects. Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex w...
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Nature Portfolio
2021
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oai:doaj.org-article:092caffa900241a1b25c21698353ff0d2021-12-02T17:40:27ZMolecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor10.1038/s41467-021-24058-z2041-1723https://doaj.org/article/092caffa900241a1b25c21698353ff0d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24058-zhttps://doaj.org/toc/2041-1723The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects. Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric Gs which offers insights into the molecular details of ago-allosterism.Zhaotong CongLi-Nan ChenHonglei MaQingtong ZhouXinyu ZouChenyu YeAntao DaiQing LiuWei HuangXianqiang SunXi WangPeiyu XuLihua ZhaoTian XiaWenge ZhongDehua YangH. Eric XuYan ZhangMing-Wei WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zhaotong Cong Li-Nan Chen Honglei Ma Qingtong Zhou Xinyu Zou Chenyu Ye Antao Dai Qing Liu Wei Huang Xianqiang Sun Xi Wang Peiyu Xu Lihua Zhao Tian Xia Wenge Zhong Dehua Yang H. Eric Xu Yan Zhang Ming-Wei Wang Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| description |
The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of glucose homeostasis and a drug target for type 2 diabetes but available GLP-1R agonists are suboptimal due to several side-effects. Here authors report the cryo-EM structure of GLP-1R bound to an ago-allosteric modulator in complex with heterotrimeric Gs which offers insights into the molecular details of ago-allosterism. |
| format |
article |
| author |
Zhaotong Cong Li-Nan Chen Honglei Ma Qingtong Zhou Xinyu Zou Chenyu Ye Antao Dai Qing Liu Wei Huang Xianqiang Sun Xi Wang Peiyu Xu Lihua Zhao Tian Xia Wenge Zhong Dehua Yang H. Eric Xu Yan Zhang Ming-Wei Wang |
| author_facet |
Zhaotong Cong Li-Nan Chen Honglei Ma Qingtong Zhou Xinyu Zou Chenyu Ye Antao Dai Qing Liu Wei Huang Xianqiang Sun Xi Wang Peiyu Xu Lihua Zhao Tian Xia Wenge Zhong Dehua Yang H. Eric Xu Yan Zhang Ming-Wei Wang |
| author_sort |
Zhaotong Cong |
| title |
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| title_short |
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| title_full |
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| title_fullStr |
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| title_full_unstemmed |
Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| title_sort |
molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/092caffa900241a1b25c21698353ff0d |
| work_keys_str_mv |
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