Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.

We previously reported that secreted phosphoprotein 1 (SPP1) mRNA is expressed in neurons whose axons form the corticospinal tract (CST) of the rhesus macaque, but not in the corresponding neurons of the marmoset and rat. This suggests that SPP1 expression is involved in the functional or structural...

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Autores principales:	Tatsuya Yamamoto, Takao Oishi, Noriyuki Higo, Shigeo Murayama, Akira Sato, Ichiro Takashima, Yoko Sugiyama, Yukio Nishimura, Yumi Murata, Kimika Yoshino-Saito, Tadashi Isa, Toshio Kojima
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/092e5c1f46294119bfab0f467f16ff05
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spelling	oai:doaj.org-article:092e5c1f46294119bfab0f467f16ff052021-11-18T07:43:23ZDifferential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.1932-620310.1371/journal.pone.0065701https://doaj.org/article/092e5c1f46294119bfab0f467f16ff052013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741508/?tool=EBIhttps://doaj.org/toc/1932-6203We previously reported that secreted phosphoprotein 1 (SPP1) mRNA is expressed in neurons whose axons form the corticospinal tract (CST) of the rhesus macaque, but not in the corresponding neurons of the marmoset and rat. This suggests that SPP1 expression is involved in the functional or structural specialization of highly developed corticospinal systems in certain primate species. To further examine this hypothesis, we evaluated the expression of SPP1 mRNA in the motor cortex from three viewpoints: species differences, postnatal development, and functional/structural changes of the CST after a lesion of the lateral CST (l-CST) at the mid-cervical level. The density of SPP1-positive neurons in layer V of the primary motor cortex (M1) was much greater in species with highly developed corticospinal systems (i.e., rhesus macaque, capuchin monkey, and humans) than in those with less developed corticospinal systems (i.e., squirrel monkey, marmoset, and rat). SPP1-positive neurons in the macaque monkey M1 increased logarithmically in layer V during postnatal development, following a time course consistent with the increase in conduction velocity of the CST. After an l-CST lesion, SPP1-positive neurons increased in layer V of the ventral premotor cortex, in which compensatory changes in CST function/structure may occur, which positively correlated with the extent of finger dexterity recovery. These results further support the concept that the expression of SPP1 may reflect functional or structural specialization of highly developed corticospinal systems in certain primate species.Tatsuya YamamotoTakao OishiNoriyuki HigoShigeo MurayamaAkira SatoIchiro TakashimaYoko SugiyamaYukio NishimuraYumi MurataKimika Yoshino-SaitoTadashi IsaToshio KojimaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e65701 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tatsuya Yamamoto Takao Oishi Noriyuki Higo Shigeo Murayama Akira Sato Ichiro Takashima Yoko Sugiyama Yukio Nishimura Yumi Murata Kimika Yoshino-Saito Tadashi Isa Toshio Kojima Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
description	We previously reported that secreted phosphoprotein 1 (SPP1) mRNA is expressed in neurons whose axons form the corticospinal tract (CST) of the rhesus macaque, but not in the corresponding neurons of the marmoset and rat. This suggests that SPP1 expression is involved in the functional or structural specialization of highly developed corticospinal systems in certain primate species. To further examine this hypothesis, we evaluated the expression of SPP1 mRNA in the motor cortex from three viewpoints: species differences, postnatal development, and functional/structural changes of the CST after a lesion of the lateral CST (l-CST) at the mid-cervical level. The density of SPP1-positive neurons in layer V of the primary motor cortex (M1) was much greater in species with highly developed corticospinal systems (i.e., rhesus macaque, capuchin monkey, and humans) than in those with less developed corticospinal systems (i.e., squirrel monkey, marmoset, and rat). SPP1-positive neurons in the macaque monkey M1 increased logarithmically in layer V during postnatal development, following a time course consistent with the increase in conduction velocity of the CST. After an l-CST lesion, SPP1-positive neurons increased in layer V of the ventral premotor cortex, in which compensatory changes in CST function/structure may occur, which positively correlated with the extent of finger dexterity recovery. These results further support the concept that the expression of SPP1 may reflect functional or structural specialization of highly developed corticospinal systems in certain primate species.
format	article
author	Tatsuya Yamamoto Takao Oishi Noriyuki Higo Shigeo Murayama Akira Sato Ichiro Takashima Yoko Sugiyama Yukio Nishimura Yumi Murata Kimika Yoshino-Saito Tadashi Isa Toshio Kojima
author_facet	Tatsuya Yamamoto Takao Oishi Noriyuki Higo Shigeo Murayama Akira Sato Ichiro Takashima Yoko Sugiyama Yukio Nishimura Yumi Murata Kimika Yoshino-Saito Tadashi Isa Toshio Kojima
author_sort	Tatsuya Yamamoto
title	Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
title_short	Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
title_full	Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
title_fullStr	Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
title_full_unstemmed	Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
title_sort	differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/092e5c1f46294119bfab0f467f16ff05
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Differential expression of secreted phosphoprotein 1 in the motor cortex among primate species and during postnatal development and functional recovery.

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