Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice

Leu-to-Phe substitution at prM146 decreases the growth ability of Zika virus and partially reduces its pathogenicity in mice

Abstract Zika virus (ZIKV) is a mosquito-borne flavivirus that causes febrile illness. The recent spread of ZIKV from Asia to the Americas via the Pacific region has revealed unprecedented features of ZIKV, including transplacental congenital infection causing microcephaly. Amino acid changes have b...

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Autores principales: Takuya Inagaki, Satoshi Taniguchi, Yasuhiro Kawai, Takahiro Maeki, Eri Nakayama, Shigeru Tajima, Haruko Takeyama, Chang Kweng Lim, Masayuki Saijo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/09300819fd214340ae09e4b3ec6fa69e
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