Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial

Abstract Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive trai...

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Autores principales:	Vinicius Souza dos Souza dos Santos, Maxciel Zortea, Rael Lopes Alves, Cátia Cilene dos Santos Naziazeno, Júlia Schirmer Saldanha, Sandra da Conceição Ribeiro de Carvalho, António Jorge da Costa Leite, Iraci Lucena da Silva Torres, Andressa de Souza, Prisla Ücker Calvetti, Felipe Fregni, Wolnei Caumo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09327a03e9d1409a81dc39dbe28f3061
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spelling	oai:doaj.org-article:09327a03e9d1409a81dc39dbe28f30612021-12-02T15:08:42ZCognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial10.1038/s41598-018-30127-z2045-2322https://doaj.org/article/09327a03e9d1409a81dc39dbe28f30612018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30127-zhttps://doaj.org/toc/2045-2322Abstract Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and working memory and its association with brain-derived neurotrophic factor (BDNF) levels. Forty females with fibromyalgia were randomized to receive eight sessions of active or sham tDCS. Anodal stimulation (2 mA) was applied over the DLPFC and online combined with a working memory training (WMT) for 20 minutes. Pre and post-treatment neurocognitive tests were administered. Data analysis on deltas considering years of education and BDNF as covariates, indicated active-tDCS + WMT significantly increased immediate memory indexed by Rey Auditory Verbal Learning Test score when compared to sham. This effect was dependent on basal BDNF levels. In addition, the model showed active stimulation increased orthographic and semantic verbal fluency scores (Controlled Oral Word Association Test) and short-term memory (Forward Digit Span). The combination of both techniques seemed to produce effects on specific cognitive functions related to short-term and long-term episodic memory and executive functions, which has clinical relevance for top-down treatment approaches in FM.Vinicius Souza dos Souza dos SantosMaxciel ZorteaRael Lopes AlvesCátia Cilene dos Santos NaziazenoJúlia Schirmer SaldanhaSandra da Conceição Ribeiro de CarvalhoAntónio Jorge da Costa LeiteIraci Lucena da Silva TorresAndressa de SouzaPrisla Ücker CalvettiFelipe FregniWolnei CaumoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vinicius Souza dos Souza dos Santos Maxciel Zortea Rael Lopes Alves Cátia Cilene dos Santos Naziazeno Júlia Schirmer Saldanha Sandra da Conceição Ribeiro de Carvalho António Jorge da Costa Leite Iraci Lucena da Silva Torres Andressa de Souza Prisla Ücker Calvetti Felipe Fregni Wolnei Caumo Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
description	Abstract Cognitive dysfunction in fibromyalgia has been reported, especially memory. Anodal transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been effective in enhancing this function. We tested the effects of eight sessions of tDCS and cognitive training on immediate and delayed memory, verbal fluency and working memory and its association with brain-derived neurotrophic factor (BDNF) levels. Forty females with fibromyalgia were randomized to receive eight sessions of active or sham tDCS. Anodal stimulation (2 mA) was applied over the DLPFC and online combined with a working memory training (WMT) for 20 minutes. Pre and post-treatment neurocognitive tests were administered. Data analysis on deltas considering years of education and BDNF as covariates, indicated active-tDCS + WMT significantly increased immediate memory indexed by Rey Auditory Verbal Learning Test score when compared to sham. This effect was dependent on basal BDNF levels. In addition, the model showed active stimulation increased orthographic and semantic verbal fluency scores (Controlled Oral Word Association Test) and short-term memory (Forward Digit Span). The combination of both techniques seemed to produce effects on specific cognitive functions related to short-term and long-term episodic memory and executive functions, which has clinical relevance for top-down treatment approaches in FM.
format	article
author	Vinicius Souza dos Souza dos Santos Maxciel Zortea Rael Lopes Alves Cátia Cilene dos Santos Naziazeno Júlia Schirmer Saldanha Sandra da Conceição Ribeiro de Carvalho António Jorge da Costa Leite Iraci Lucena da Silva Torres Andressa de Souza Prisla Ücker Calvetti Felipe Fregni Wolnei Caumo
author_facet	Vinicius Souza dos Souza dos Santos Maxciel Zortea Rael Lopes Alves Cátia Cilene dos Santos Naziazeno Júlia Schirmer Saldanha Sandra da Conceição Ribeiro de Carvalho António Jorge da Costa Leite Iraci Lucena da Silva Torres Andressa de Souza Prisla Ücker Calvetti Felipe Fregni Wolnei Caumo
author_sort	Vinicius Souza dos Souza dos Santos
title	Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
title_short	Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
title_full	Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
title_fullStr	Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
title_full_unstemmed	Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
title_sort	cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/09327a03e9d1409a81dc39dbe28f3061
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Cognitive effects of transcranial direct current stimulation combined with working memory training in fibromyalgia: a randomized clinical trial

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