QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.

<h4>Aim</h4>To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared...

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Autores principales:	Michala V Rose, Godfather Kimaro, Thomas N Nissen, Inge Kroidl, Michael Hoelscher, Ib C Bygbjerg, Sayoki G Mfinanga, Pernille Ravn
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/09347c2a2414442e84347ed5255f4c70
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spelling	oai:doaj.org-article:09347c2a2414442e84347ed5255f4c702021-11-18T07:12:43ZQuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.1932-620310.1371/journal.pone.0037851https://doaj.org/article/09347c2a2414442e84347ed5255f4c702012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22808002/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Aim</h4>To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania.<h4>Methods</h4>Sensitivity and specificity of QFT and TST for diagnosing active TB as well as indeterminate QFT rates and IFN-γ levels were assessed in 211 TB suspect children in a Tanzanian district hospital and contrasted in 90 adults with confirmed pulmonary TB.<h4>Results</h4>Sensitivity of QFT and TST in children with confirmed TB was 19% (5/27) and 6% (2/31) respectively. In adults sensitivity of QFT and TST was 84% (73/87) and 85% (63/74). The QFT indeterminate rate in children and adults was 27% and 3%. Median levels of IFN-γ were lower in children than adults, particularly children <2 years and HIV infected. An indeterminate result was associated with age <2 years but not malnutrition or HIV status. Overall childhood mortality was 19% and associated with an indeterminate QFT result at baseline.<h4>Conclusion</h4>QFT and TST showed poor performance and a surprisingly low sensitivity in children. In contrast the performance in Tanzanian adults was good and comparable to performance in high-income countries. Indeterminate results in children were associated with young age and increased mortality. Neither test can be recommended for diagnosing active TB in children with immature or impaired immunity in a high-burden setting.Michala V RoseGodfather KimaroThomas N NissenInge KroidlMichael HoelscherIb C BygbjergSayoki G MfinangaPernille RavnPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e37851 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michala V Rose Godfather Kimaro Thomas N Nissen Inge Kroidl Michael Hoelscher Ib C Bygbjerg Sayoki G Mfinanga Pernille Ravn QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
description	<h4>Aim</h4>To determine whether QuantiFERON®-TB Gold In-Tube (QFT) can contribute to the diagnosis of active tuberculosis (TB) in children in a high-burden setting and to assess the performance of QFT and tuberculin skin test (TST) in a prospective cohort of TB suspect children compared to adults with confirmed TB in Tanzania.<h4>Methods</h4>Sensitivity and specificity of QFT and TST for diagnosing active TB as well as indeterminate QFT rates and IFN-γ levels were assessed in 211 TB suspect children in a Tanzanian district hospital and contrasted in 90 adults with confirmed pulmonary TB.<h4>Results</h4>Sensitivity of QFT and TST in children with confirmed TB was 19% (5/27) and 6% (2/31) respectively. In adults sensitivity of QFT and TST was 84% (73/87) and 85% (63/74). The QFT indeterminate rate in children and adults was 27% and 3%. Median levels of IFN-γ were lower in children than adults, particularly children <2 years and HIV infected. An indeterminate result was associated with age <2 years but not malnutrition or HIV status. Overall childhood mortality was 19% and associated with an indeterminate QFT result at baseline.<h4>Conclusion</h4>QFT and TST showed poor performance and a surprisingly low sensitivity in children. In contrast the performance in Tanzanian adults was good and comparable to performance in high-income countries. Indeterminate results in children were associated with young age and increased mortality. Neither test can be recommended for diagnosing active TB in children with immature or impaired immunity in a high-burden setting.
format	article
author	Michala V Rose Godfather Kimaro Thomas N Nissen Inge Kroidl Michael Hoelscher Ib C Bygbjerg Sayoki G Mfinanga Pernille Ravn
author_facet	Michala V Rose Godfather Kimaro Thomas N Nissen Inge Kroidl Michael Hoelscher Ib C Bygbjerg Sayoki G Mfinanga Pernille Ravn
author_sort	Michala V Rose
title	QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
title_short	QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
title_full	QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
title_fullStr	QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
title_full_unstemmed	QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
title_sort	quantiferon®-tb gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/09347c2a2414442e84347ed5255f4c70
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QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting.

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