An embryonic stem cell-specific heterochromatin state promotes core histone exchange in the absence of DNA accessibility

Nucleosome turnover concomitant with incorporation of the histone variant H3.3 is a hallmark of regulatory regions in the animal genome. Here, the authors demonstrate that fast histone turnover and H3.3 incorporation defines a dynamic heterochromatin state in pluripotent stem cells.

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Autores principales: Carmen Navarro, Jing Lyu, Anna-Maria Katsori, Rozina Caridha, Simon J. Elsässer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/0935d9b38bff4e838fc9ea0b408a07b4
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