Thirteen-week inhalation toxicity study of 1-propanol in F344 rats

1-Propanol is a colorless volatile liquid at room temperature and is an important industrial alcohol. Workers are potentially exposed to it through inhalation during industrial activities, including manufacturing, sampling, filling, and mixing processes, as well as during cleaning, maintenance, and...

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Autores principales:	Yong-Soon Kim, Ka-Young Park, Eun-Sang Cho
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Inhalation toxicity study No-observed-adverse-concentration level Occupational exposure 1-Propanol Toxicology. Poisons RA1190-1270
Acceso en línea:	https://doaj.org/article/09361b0d5b81489382d0e4f146863d9e
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spelling	oai:doaj.org-article:09361b0d5b81489382d0e4f146863d9e2021-11-10T04:27:41ZThirteen-week inhalation toxicity study of 1-propanol in F344 rats2214-750010.1016/j.toxrep.2021.11.004https://doaj.org/article/09361b0d5b81489382d0e4f146863d9e2021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2214750021001888https://doaj.org/toc/2214-75001-Propanol is a colorless volatile liquid at room temperature and is an important industrial alcohol. Workers are potentially exposed to it through inhalation during industrial activities, including manufacturing, sampling, filling, and mixing processes, as well as during cleaning, maintenance, and repair. Consequently, further information and/or testing for inhalation-related toxicological data is required to assess occupational risk. In this study, 80 (40 male and 40 female) F344 rats were exposed to 1-propanol vapors for 13 weeks (6 h a day, 5 days per week) at target concentrations of 0, 500, 1,600, and 5200 ppm in a whole-body inhalation chamber system. Clinical signs, mean body weight changes, food consumption, hematology, blood biochemistry, necropsy, organ weight, and histopathological findings were observed. The exposure concentrations in chambers were 501.30 ± 9.54 ppm, 1605.43 ± 66.55 ppm, and 5202.19 ± 102.74 ppm for the low, middle, and high dose groups, respectively. No changes related to 1-propanol were observed, including histopathological findings, except for mean body weight changes. The significant decrease in mean body weight at a high dose was not considered to be an adverse effect. Based on these results, the no observed adverse effect concentration of 1-propanol was estimated to be 5202.19 ppm.Yong-Soon KimKa-Young ParkEun-Sang ChoElsevierarticleInhalation toxicity studyNo-observed-adverse-concentration levelOccupational exposure1-PropanolToxicology. PoisonsRA1190-1270ENToxicology Reports, Vol 8, Iss , Pp 1839-1845 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inhalation toxicity study No-observed-adverse-concentration level Occupational exposure 1-Propanol Toxicology. Poisons RA1190-1270
spellingShingle	Inhalation toxicity study No-observed-adverse-concentration level Occupational exposure 1-Propanol Toxicology. Poisons RA1190-1270 Yong-Soon Kim Ka-Young Park Eun-Sang Cho Thirteen-week inhalation toxicity study of 1-propanol in F344 rats
description	1-Propanol is a colorless volatile liquid at room temperature and is an important industrial alcohol. Workers are potentially exposed to it through inhalation during industrial activities, including manufacturing, sampling, filling, and mixing processes, as well as during cleaning, maintenance, and repair. Consequently, further information and/or testing for inhalation-related toxicological data is required to assess occupational risk. In this study, 80 (40 male and 40 female) F344 rats were exposed to 1-propanol vapors for 13 weeks (6 h a day, 5 days per week) at target concentrations of 0, 500, 1,600, and 5200 ppm in a whole-body inhalation chamber system. Clinical signs, mean body weight changes, food consumption, hematology, blood biochemistry, necropsy, organ weight, and histopathological findings were observed. The exposure concentrations in chambers were 501.30 ± 9.54 ppm, 1605.43 ± 66.55 ppm, and 5202.19 ± 102.74 ppm for the low, middle, and high dose groups, respectively. No changes related to 1-propanol were observed, including histopathological findings, except for mean body weight changes. The significant decrease in mean body weight at a high dose was not considered to be an adverse effect. Based on these results, the no observed adverse effect concentration of 1-propanol was estimated to be 5202.19 ppm.
format	article
author	Yong-Soon Kim Ka-Young Park Eun-Sang Cho
author_facet	Yong-Soon Kim Ka-Young Park Eun-Sang Cho
author_sort	Yong-Soon Kim
title	Thirteen-week inhalation toxicity study of 1-propanol in F344 rats
title_short	Thirteen-week inhalation toxicity study of 1-propanol in F344 rats
title_full	Thirteen-week inhalation toxicity study of 1-propanol in F344 rats
title_fullStr	Thirteen-week inhalation toxicity study of 1-propanol in F344 rats
title_full_unstemmed	Thirteen-week inhalation toxicity study of 1-propanol in F344 rats
title_sort	thirteen-week inhalation toxicity study of 1-propanol in f344 rats
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/09361b0d5b81489382d0e4f146863d9e
work_keys_str_mv	AT yongsoonkim thirteenweekinhalationtoxicitystudyof1propanolinf344rats AT kayoungpark thirteenweekinhalationtoxicitystudyof1propanolinf344rats AT eunsangcho thirteenweekinhalationtoxicitystudyof1propanolinf344rats
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Thirteen-week inhalation toxicity study of 1-propanol in F344 rats

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