CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus...
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| Auteurs principaux: | , , , , , , |
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| Format: | article |
| Langue: | RU |
| Publié: |
SPb RAACI
2014
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| Accès en ligne: | https://doaj.org/article/0936c546bbad4f99a0485a32fd4444f8 |
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| Résumé: | Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology. |
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