CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD

Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus...

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Autores principales:	O. T. Kudaeva, V. O. Tkachev, E. D. Gavrilova, E. V. Goiman, N. N. Volsky, O. M. Perminova, O. P. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chronic gvhd cytokines immunoglobulin e Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/0936c546bbad4f99a0485a32fd4444f8
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spelling	oai:doaj.org-article:0936c546bbad4f99a0485a32fd4444f82021-11-18T08:03:39ZCYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD1563-06252313-741X10.15789/1563-0625-2012-1-2-67-74https://doaj.org/article/0936c546bbad4f99a0485a32fd4444f82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/298https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology.O. T. KudaevaV. O. TkachevE. D. GavrilovaE. V. GoimanN. N. VolskyO. M. PerminovaO. P. KolesnikovaSPb RAACIarticlechronic gvhdcytokinesimmunoglobulin eImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 67-74 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chronic gvhd cytokines immunoglobulin e Immunologic diseases. Allergy RC581-607
spellingShingle	chronic gvhd cytokines immunoglobulin e Immunologic diseases. Allergy RC581-607 O. T. Kudaeva V. O. Tkachev E. D. Gavrilova E. V. Goiman N. N. Volsky O. M. Perminova O. P. Kolesnikova CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
description	Abstract. Induction of chronic GVHD in the DBA/2→(C57Bl/6xDBA/2) F1 semi-allogeneic murine model results into development of Th1- and Th2-dependent immunopathological conditions that are characterized by different cytokine profiles. Chronic GVHD is accompanied by a sharp increase in IgE levels, thus presuming considerable IL-4 production. In recipients with Th2-dependent GvHD variant, elevated contents of serum IL-6, IL-7 and TNFα were also observed, which, along with other effects, may support polyclonal activation of B cells, thus leading to development of autoimmune pathology.
format	article
author	O. T. Kudaeva V. O. Tkachev E. D. Gavrilova E. V. Goiman N. N. Volsky O. M. Perminova O. P. Kolesnikova
author_facet	O. T. Kudaeva V. O. Tkachev E. D. Gavrilova E. V. Goiman N. N. Volsky O. M. Perminova O. P. Kolesnikova
author_sort	O. T. Kudaeva
title	CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
title_short	CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
title_full	CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
title_fullStr	CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
title_full_unstemmed	CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD
title_sort	cytokine profile of th1- and th2-dependent variants of chronic gvhd
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/0936c546bbad4f99a0485a32fd4444f8
work_keys_str_mv	AT otkudaeva cytokineprofileofth1andth2dependentvariantsofchronicgvhd AT votkachev cytokineprofileofth1andth2dependentvariantsofchronicgvhd AT edgavrilova cytokineprofileofth1andth2dependentvariantsofchronicgvhd AT evgoiman cytokineprofileofth1andth2dependentvariantsofchronicgvhd AT nnvolsky cytokineprofileofth1andth2dependentvariantsofchronicgvhd AT omperminova cytokineprofileofth1andth2dependentvariantsofchronicgvhd AT opkolesnikova cytokineprofileofth1andth2dependentvariantsofchronicgvhd
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CYTOKINE PROFILE OF TH1- AND TH2-DEPENDENT VARIANTS OF CHRONIC GVHD

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