A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico
In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different p...
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MDPI AG
2021
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oai:doaj.org-article:09375b10711b4c5892a8d69a8ecd1ab32021-11-25T19:07:58ZA Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico10.3390/toxics91102722305-6304https://doaj.org/article/09375b10711b4c5892a8d69a8ecd1ab32021-10-01T00:00:00Zhttps://www.mdpi.com/2305-6304/9/11/272https://doaj.org/toc/2305-6304In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different pests. Besides measuring their levels or that of their metabolites in air, plasma, serum, blood, urine, etc., some studies reported increased DNA damage levels after occupational or environmental pesticides exposure, evidenced by several cytogenetic biomarkers such as chromosomal aberrations (CA), sister chromatid exchanges (SCE), micronuclei frequency (MN) together with other nuclear abnormalities (NA), alkaline comet assay, but also changes in oxidative stress parameters and miRNA levels. Single or combined, these techniques have also been used in genotoxic biomonitoring studies of workers occupationally exposed to pesticides in Mexico. Despite being a country with great agricultural activity and reported excessive pesticide use, genotoxic studies have been relatively few and, in some cases, contradictory. A review was made of the studies available (published until the end of 2020 on PubMed, Web of Science, Redalyc and Scielo, both in English and Spanish) in the scientific literature that evaluated occupational exposure of human samples to pesticides assessed with DNA damage and related biomarkers in Mexico.Juana Sánchez-AlarcónMirta MilićVilena KašubaMaría Guadalupe Tenorio-ArvideJosé Mariano Rigoberto Montiel-GonzálezStefano BonassiRafael Valencia-QuintanaMDPI AGarticlecomet assayDNA damagemicronucleus assaynuclear abnormalitiessisters’ chromatid exchangeChemical technologyTP1-1185ENToxics, Vol 9, Iss 272, p 272 (2021) |
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comet assay DNA damage micronucleus assay nuclear abnormalities sisters’ chromatid exchange Chemical technology TP1-1185 |
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comet assay DNA damage micronucleus assay nuclear abnormalities sisters’ chromatid exchange Chemical technology TP1-1185 Juana Sánchez-Alarcón Mirta Milić Vilena Kašuba María Guadalupe Tenorio-Arvide José Mariano Rigoberto Montiel-González Stefano Bonassi Rafael Valencia-Quintana A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico |
| description |
In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different pests. Besides measuring their levels or that of their metabolites in air, plasma, serum, blood, urine, etc., some studies reported increased DNA damage levels after occupational or environmental pesticides exposure, evidenced by several cytogenetic biomarkers such as chromosomal aberrations (CA), sister chromatid exchanges (SCE), micronuclei frequency (MN) together with other nuclear abnormalities (NA), alkaline comet assay, but also changes in oxidative stress parameters and miRNA levels. Single or combined, these techniques have also been used in genotoxic biomonitoring studies of workers occupationally exposed to pesticides in Mexico. Despite being a country with great agricultural activity and reported excessive pesticide use, genotoxic studies have been relatively few and, in some cases, contradictory. A review was made of the studies available (published until the end of 2020 on PubMed, Web of Science, Redalyc and Scielo, both in English and Spanish) in the scientific literature that evaluated occupational exposure of human samples to pesticides assessed with DNA damage and related biomarkers in Mexico. |
| format |
article |
| author |
Juana Sánchez-Alarcón Mirta Milić Vilena Kašuba María Guadalupe Tenorio-Arvide José Mariano Rigoberto Montiel-González Stefano Bonassi Rafael Valencia-Quintana |
| author_facet |
Juana Sánchez-Alarcón Mirta Milić Vilena Kašuba María Guadalupe Tenorio-Arvide José Mariano Rigoberto Montiel-González Stefano Bonassi Rafael Valencia-Quintana |
| author_sort |
Juana Sánchez-Alarcón |
| title |
A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico |
| title_short |
A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico |
| title_full |
A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico |
| title_fullStr |
A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico |
| title_full_unstemmed |
A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico |
| title_sort |
systematic review of studies on genotoxicity and related biomarkers in populations exposed to pesticides in mexico |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/09375b10711b4c5892a8d69a8ecd1ab3 |
| work_keys_str_mv |
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| _version_ |
1718410258133549056 |