Oxyresveratrol modulates the immune response in vitro

The naturally occurring stilbenoid oxyresveratrol was shown to influence inflammatory and metabolic processes. During cellular immune activation, tryptophan breakdown and neopterin formation via the enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and GTP-cyclohydrolase, respectively, are induced. Neop...

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Autores principales:	Palabiyik-Yucelik Saziye Sezin, Moser Simone, Becker Kathrin, Halici Zekai, Bayir Yasin, Stonig Marlies, Schennach Harald, Fuchs Dietmar, Gostner Johanna M., Kurz Katharina
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	oxyresveratrol tryptophan breakdown neopterin pbmc thp-1 Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/09384b9091a649acba6b6ea8fd6aeda5
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id	oai:doaj.org-article:09384b9091a649acba6b6ea8fd6aeda5
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spelling	oai:doaj.org-article:09384b9091a649acba6b6ea8fd6aeda52021-12-05T14:11:02ZOxyresveratrol modulates the immune response in vitro2195-472010.1515/pteridines-2020-0029https://doaj.org/article/09384b9091a649acba6b6ea8fd6aeda52021-10-01T00:00:00Zhttps://doi.org/10.1515/pteridines-2020-0029https://doaj.org/toc/2195-4720The naturally occurring stilbenoid oxyresveratrol was shown to influence inflammatory and metabolic processes. During cellular immune activation, tryptophan breakdown and neopterin formation via the enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and GTP-cyclohydrolase, respectively, are induced. Neopterin and the kynurenine to tryptophan ratio are reliable and pertinent biomarkers of Th1-type immune response and are also used in vitro to monitor effects of active plant ingredients on peripheral blood mononuclear cells (PBMCs). We investigated the effects of oxyresveratrol on the activity of the above-mentioned pathways in mitogen-stimulated human PBMC and in the myelomonocytic cell line THP-1. Oxyresveratrol exerted suppressive effects on tryptophan breakdown in both stimulated cell models. Of note, in PBMC, tryptophan breakdown was induced at lower concentrations (5–20 µM) and suppressed at higher treatment concentrations only. Neopterin formation was decreased dose-dependently in stimulated PBMC. In unstimulated PBMC similar, albeit lesser effects were observed. Data indicate that oxyresveratrol exerts distinct and concentration-dependent effects on different immune cell types. IDO-1 is targeted by oxyresveratrol and its activity can be modulated in both directions. Detailed investigations of the interactions would be interesting to fully explore the activity of this phytocompound.Palabiyik-Yucelik Saziye SezinMoser SimoneBecker KathrinHalici ZekaiBayir YasinStonig MarliesSchennach HaraldFuchs DietmarGostner Johanna M.Kurz KatharinaDe Gruyterarticleoxyresveratroltryptophan breakdownneopterinpbmcthp-1CrystallographyQD901-999ENPteridines, Vol 32, Iss 1, Pp 70-78 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oxyresveratrol tryptophan breakdown neopterin pbmc thp-1 Crystallography QD901-999
spellingShingle	oxyresveratrol tryptophan breakdown neopterin pbmc thp-1 Crystallography QD901-999 Palabiyik-Yucelik Saziye Sezin Moser Simone Becker Kathrin Halici Zekai Bayir Yasin Stonig Marlies Schennach Harald Fuchs Dietmar Gostner Johanna M. Kurz Katharina Oxyresveratrol modulates the immune response in vitro
description	The naturally occurring stilbenoid oxyresveratrol was shown to influence inflammatory and metabolic processes. During cellular immune activation, tryptophan breakdown and neopterin formation via the enzymes indoleamine 2,3-dioxygenase-1 (IDO-1) and GTP-cyclohydrolase, respectively, are induced. Neopterin and the kynurenine to tryptophan ratio are reliable and pertinent biomarkers of Th1-type immune response and are also used in vitro to monitor effects of active plant ingredients on peripheral blood mononuclear cells (PBMCs). We investigated the effects of oxyresveratrol on the activity of the above-mentioned pathways in mitogen-stimulated human PBMC and in the myelomonocytic cell line THP-1. Oxyresveratrol exerted suppressive effects on tryptophan breakdown in both stimulated cell models. Of note, in PBMC, tryptophan breakdown was induced at lower concentrations (5–20 µM) and suppressed at higher treatment concentrations only. Neopterin formation was decreased dose-dependently in stimulated PBMC. In unstimulated PBMC similar, albeit lesser effects were observed. Data indicate that oxyresveratrol exerts distinct and concentration-dependent effects on different immune cell types. IDO-1 is targeted by oxyresveratrol and its activity can be modulated in both directions. Detailed investigations of the interactions would be interesting to fully explore the activity of this phytocompound.
format	article
author	Palabiyik-Yucelik Saziye Sezin Moser Simone Becker Kathrin Halici Zekai Bayir Yasin Stonig Marlies Schennach Harald Fuchs Dietmar Gostner Johanna M. Kurz Katharina
author_facet	Palabiyik-Yucelik Saziye Sezin Moser Simone Becker Kathrin Halici Zekai Bayir Yasin Stonig Marlies Schennach Harald Fuchs Dietmar Gostner Johanna M. Kurz Katharina
author_sort	Palabiyik-Yucelik Saziye Sezin
title	Oxyresveratrol modulates the immune response in vitro
title_short	Oxyresveratrol modulates the immune response in vitro
title_full	Oxyresveratrol modulates the immune response in vitro
title_fullStr	Oxyresveratrol modulates the immune response in vitro
title_full_unstemmed	Oxyresveratrol modulates the immune response in vitro
title_sort	oxyresveratrol modulates the immune response in vitro
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/09384b9091a649acba6b6ea8fd6aeda5
work_keys_str_mv	AT palabiyikyuceliksaziyesezin oxyresveratrolmodulatestheimmuneresponseinvitro AT mosersimone oxyresveratrolmodulatestheimmuneresponseinvitro AT beckerkathrin oxyresveratrolmodulatestheimmuneresponseinvitro AT halicizekai oxyresveratrolmodulatestheimmuneresponseinvitro AT bayiryasin oxyresveratrolmodulatestheimmuneresponseinvitro AT stonigmarlies oxyresveratrolmodulatestheimmuneresponseinvitro AT schennachharald oxyresveratrolmodulatestheimmuneresponseinvitro AT fuchsdietmar oxyresveratrolmodulatestheimmuneresponseinvitro AT gostnerjohannam oxyresveratrolmodulatestheimmuneresponseinvitro AT kurzkatharina oxyresveratrolmodulatestheimmuneresponseinvitro
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Oxyresveratrol modulates the immune response in vitro

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