Molecular basis of microhomology-mediated end-joining by purified full-length Polθ
DNA polymerase θ is a polymerase-helicase essential for microhomology-mediated end-joining (MMEJ) or alternative end-joining of DNA. Here the authors use biochemical and biophysical methods to reveal how full-length human DNA polymerase θ performs MMEJ at the molecular level.
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Nature Portfolio
2019
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oai:doaj.org-article:093c0d5069da4980a49ad192ca552eb02021-12-02T16:57:10ZMolecular basis of microhomology-mediated end-joining by purified full-length Polθ10.1038/s41467-019-12272-92041-1723https://doaj.org/article/093c0d5069da4980a49ad192ca552eb02019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12272-9https://doaj.org/toc/2041-1723DNA polymerase θ is a polymerase-helicase essential for microhomology-mediated end-joining (MMEJ) or alternative end-joining of DNA. Here the authors use biochemical and biophysical methods to reveal how full-length human DNA polymerase θ performs MMEJ at the molecular level.Samuel J. BlackAhmet Y. OzdemirEkaterina KashkinaTatiana KentTimur RusanovDejan RisticYeonoh ShinAntonio SumaTrung HoangGurushankar ChandramoulyLabiba A. SiddiqueNikita BorisonnikKatherine Sullivan-ReedJoseph S. MallonTomasz SkorskiVincenzo CarnevaleKatsuhiko S. MurakamiClaire WymanRichard T. PomerantzNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Samuel J. Black Ahmet Y. Ozdemir Ekaterina Kashkina Tatiana Kent Timur Rusanov Dejan Ristic Yeonoh Shin Antonio Suma Trung Hoang Gurushankar Chandramouly Labiba A. Siddique Nikita Borisonnik Katherine Sullivan-Reed Joseph S. Mallon Tomasz Skorski Vincenzo Carnevale Katsuhiko S. Murakami Claire Wyman Richard T. Pomerantz Molecular basis of microhomology-mediated end-joining by purified full-length Polθ |
| description |
DNA polymerase θ is a polymerase-helicase essential for microhomology-mediated end-joining (MMEJ) or alternative end-joining of DNA. Here the authors use biochemical and biophysical methods to reveal how full-length human DNA polymerase θ performs MMEJ at the molecular level. |
| format |
article |
| author |
Samuel J. Black Ahmet Y. Ozdemir Ekaterina Kashkina Tatiana Kent Timur Rusanov Dejan Ristic Yeonoh Shin Antonio Suma Trung Hoang Gurushankar Chandramouly Labiba A. Siddique Nikita Borisonnik Katherine Sullivan-Reed Joseph S. Mallon Tomasz Skorski Vincenzo Carnevale Katsuhiko S. Murakami Claire Wyman Richard T. Pomerantz |
| author_facet |
Samuel J. Black Ahmet Y. Ozdemir Ekaterina Kashkina Tatiana Kent Timur Rusanov Dejan Ristic Yeonoh Shin Antonio Suma Trung Hoang Gurushankar Chandramouly Labiba A. Siddique Nikita Borisonnik Katherine Sullivan-Reed Joseph S. Mallon Tomasz Skorski Vincenzo Carnevale Katsuhiko S. Murakami Claire Wyman Richard T. Pomerantz |
| author_sort |
Samuel J. Black |
| title |
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ |
| title_short |
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ |
| title_full |
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ |
| title_fullStr |
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ |
| title_full_unstemmed |
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ |
| title_sort |
molecular basis of microhomology-mediated end-joining by purified full-length polθ |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/093c0d5069da4980a49ad192ca552eb0 |
| work_keys_str_mv |
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1718382604372148224 |