Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review

Circular RNAs (circRNAs) are a complicated class of non-coding RNAs that have a covalently closed loop structure and are very stable and cautious. Multiple biological processes of malignancy, including tumorigenesis, development, invasion, metastasis, apoptosis, and vascularization, are disrupted by...

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Autores principales:	Seyedeh Zahra Bakhti, Sana Dadashi, Anahita Dah Pahlevan, Fatemeh Kafshresan
Formato:	article
Lenguaje:	EN
Publicado:	Shahid Beheshti University of Medical Sciences 2021
Materias:	circrnas mirna brain glioma glioblastoma Medicine R
Acceso en línea:	https://doaj.org/article/093c92c2a76a49a58100820ac3d400a9
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spelling	oai:doaj.org-article:093c92c2a76a49a58100820ac3d400a92021-11-16T10:51:30ZFunctional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review2383-18712383-209610.34172/icnj.2021.33https://doaj.org/article/093c92c2a76a49a58100820ac3d400a92021-10-01T00:00:00Zhttps://journals.sbmu.ac.ir/neuroscience/article/view/35141/27917https://doaj.org/toc/2383-1871https://doaj.org/toc/2383-2096Circular RNAs (circRNAs) are a complicated class of non-coding RNAs that have a covalently closed loop structure and are very stable and cautious. Multiple biological processes of malignancy, including tumorigenesis, development, invasion, metastasis, apoptosis, and vascularization, are disrupted by an increased number of circRNAs. Recent research has showed that circRNAs, functioning as microRNA (miRNA) sponges or protein scaffolds, interacting with RNA-binding proteins (RBPs), and autophagy regulators, affect the transcription and splicing regulation. Many circRNAs have tissue-specific expression patterns and are heavily conserved. CircRNA levels in neurons are dynamically modulated. Growing evidence suggests that circRNAs are highly abundant in neural tissues, perhaps owing to the proliferation of particular genes that promote circularization, implying that circRNA dysregulation is linked to nervous system disorders including glioma. The most widespread and deadly primary malignant brain tumor is glioma. CircRNA has a close connection to glioma, according to reported research. Here, the current knowledge about the properties of circRNAs is introduced and the biological and molecular functions of circRNAs are described. Then, the clinical association of circRNAs with glioma/glioblastoma and their level of expression and their regulatory mechanisms in tumorigenesis are discussed. Moreover, the potential of circRNAs as diagnostic biomarkers and predictors of brain cancer risk and possible therapeutic targets in medicine is examined.Seyedeh Zahra BakhtiSana DadashiAnahita Dah PahlevanFatemeh KafshresanShahid Beheshti University of Medical SciencesarticlecircrnasmirnabraingliomaglioblastomaMedicineRENInternational Clinical Neuroscience Journal, Vol 8, Iss 4, Pp 157-167 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circrnas mirna brain glioma glioblastoma Medicine R
spellingShingle	circrnas mirna brain glioma glioblastoma Medicine R Seyedeh Zahra Bakhti Sana Dadashi Anahita Dah Pahlevan Fatemeh Kafshresan Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review
description	Circular RNAs (circRNAs) are a complicated class of non-coding RNAs that have a covalently closed loop structure and are very stable and cautious. Multiple biological processes of malignancy, including tumorigenesis, development, invasion, metastasis, apoptosis, and vascularization, are disrupted by an increased number of circRNAs. Recent research has showed that circRNAs, functioning as microRNA (miRNA) sponges or protein scaffolds, interacting with RNA-binding proteins (RBPs), and autophagy regulators, affect the transcription and splicing regulation. Many circRNAs have tissue-specific expression patterns and are heavily conserved. CircRNA levels in neurons are dynamically modulated. Growing evidence suggests that circRNAs are highly abundant in neural tissues, perhaps owing to the proliferation of particular genes that promote circularization, implying that circRNA dysregulation is linked to nervous system disorders including glioma. The most widespread and deadly primary malignant brain tumor is glioma. CircRNA has a close connection to glioma, according to reported research. Here, the current knowledge about the properties of circRNAs is introduced and the biological and molecular functions of circRNAs are described. Then, the clinical association of circRNAs with glioma/glioblastoma and their level of expression and their regulatory mechanisms in tumorigenesis are discussed. Moreover, the potential of circRNAs as diagnostic biomarkers and predictors of brain cancer risk and possible therapeutic targets in medicine is examined.
format	article
author	Seyedeh Zahra Bakhti Sana Dadashi Anahita Dah Pahlevan Fatemeh Kafshresan
author_facet	Seyedeh Zahra Bakhti Sana Dadashi Anahita Dah Pahlevan Fatemeh Kafshresan
author_sort	Seyedeh Zahra Bakhti
title	Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review
title_short	Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review
title_full	Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review
title_fullStr	Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review
title_full_unstemmed	Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review
title_sort	functional roles and biological mechanisms of circular rnas and their encoded peptides in glioma: a narrative review
publisher	Shahid Beheshti University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/093c92c2a76a49a58100820ac3d400a9
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Functional Roles and Biological Mechanisms of Circular RNAs and Their Encoded Peptides in Glioma: A Narrative Review

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