Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes

In genome-wide association studies, variant-level associations are hard to identify and can be difficult to interpret biologically. Here, the authors develop a new model-based enrichment analysis method, and apply it to identify new associated genes, pathways and tissues across 31 human phenotypes.

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Autores principales: Xiang Zhu, Matthew Stephens
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/09415081d3744dba8f88983498596104
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spelling oai:doaj.org-article:09415081d3744dba8f889834985961042021-12-02T14:40:02ZLarge-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes10.1038/s41467-018-06805-x2041-1723https://doaj.org/article/09415081d3744dba8f889834985961042018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06805-xhttps://doaj.org/toc/2041-1723In genome-wide association studies, variant-level associations are hard to identify and can be difficult to interpret biologically. Here, the authors develop a new model-based enrichment analysis method, and apply it to identify new associated genes, pathways and tissues across 31 human phenotypes.Xiang ZhuMatthew StephensNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiang Zhu
Matthew Stephens
Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
description In genome-wide association studies, variant-level associations are hard to identify and can be difficult to interpret biologically. Here, the authors develop a new model-based enrichment analysis method, and apply it to identify new associated genes, pathways and tissues across 31 human phenotypes.
format article
author Xiang Zhu
Matthew Stephens
author_facet Xiang Zhu
Matthew Stephens
author_sort Xiang Zhu
title Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
title_short Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
title_full Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
title_fullStr Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
title_full_unstemmed Large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
title_sort large-scale genome-wide enrichment analyses identify new trait-associated genes and pathways across 31 human phenotypes
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/09415081d3744dba8f88983498596104
work_keys_str_mv AT xiangzhu largescalegenomewideenrichmentanalysesidentifynewtraitassociatedgenesandpathwaysacross31humanphenotypes
AT matthewstephens largescalegenomewideenrichmentanalysesidentifynewtraitassociatedgenesandpathwaysacross31humanphenotypes
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