Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains uncle...

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Autores principales:	Jackwee Lim, Kia Joo Puan, Liang Wei Wang, Karen Wei Weng Teng, Chiew Yee Loh, Kim Peng Tan, Guillaume Carissimo, Yi-Hao Chan, Chek Meng Poh, Cheryl Yi-Pin Lee, Siew-Wai Fong, Nicholas Kim-Wah Yeo, Rhonda Sin-Ling Chee, Siti Naqiah Amrun, Zi Wei Chang, Matthew Zirui Tay, Anthony Torres-Ruesta, Norman Leo Fernandez, Wilson How, Anand Kumar Andiappan, Wendy Lee, Kaibo Duan, Seow-Yen Tan, Gabriel Yan, Shirin Kalimuddin, David Chien Lye, Yee-Sin Leo, Sean W. X. Ong, Barnaby E. Young, Laurent Renia, Lisa F. P. Ng, Bernett Lee, Olaf Rötzschke
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 cytokine profile severity SARS – CoV – 2 inflammation active infection Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/09415a4209cb486cbf1d519aa8d7c6ff
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spelling	oai:doaj.org-article:09415a4209cb486cbf1d519aa8d7c6ff2021-11-19T07:52:57ZData-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals1664-322410.3389/fimmu.2021.710217https://doaj.org/article/09415a4209cb486cbf1d519aa8d7c6ff2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.710217/fullhttps://doaj.org/toc/1664-3224Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and Vδ2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of “long COVID-19”, and defines key cells and cytokines that delineate true and quasi-convalescent states.Jackwee LimKia Joo PuanLiang Wei WangKaren Wei Weng TengChiew Yee LohKim Peng TanGuillaume CarissimoGuillaume CarissimoYi-Hao ChanYi-Hao ChanChek Meng PohChek Meng PohCheryl Yi-Pin LeeCheryl Yi-Pin LeeSiew-Wai FongSiew-Wai FongSiew-Wai FongNicholas Kim-Wah YeoNicholas Kim-Wah YeoRhonda Sin-Ling CheeRhonda Sin-Ling CheeSiti Naqiah AmrunSiti Naqiah AmrunZi Wei ChangZi Wei ChangMatthew Zirui TayMatthew Zirui TayAnthony Torres-RuestaAnthony Torres-RuestaAnthony Torres-RuestaNorman Leo FernandezWilson HowAnand Kumar AndiappanWendy LeeKaibo DuanSeow-Yen TanGabriel YanShirin KalimuddinShirin KalimuddinDavid Chien LyeDavid Chien LyeDavid Chien LyeDavid Chien LyeYee-Sin LeoYee-Sin LeoYee-Sin LeoYee-Sin LeoYee-Sin LeoSean W. X. OngSean W. X. OngBarnaby E. YoungBarnaby E. YoungBarnaby E. YoungLaurent ReniaLaurent ReniaLisa F. P. NgLisa F. P. NgLisa F. P. NgLisa F. P. NgBernett LeeOlaf RötzschkeFrontiers Media S.A.articleCOVID-19cytokine profileseveritySARS – CoV – 2inflammationactive infectionImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 cytokine profile severity SARS – CoV – 2 inflammation active infection Immunologic diseases. Allergy RC581-607
spellingShingle	COVID-19 cytokine profile severity SARS – CoV – 2 inflammation active infection Immunologic diseases. Allergy RC581-607 Jackwee Lim Kia Joo Puan Liang Wei Wang Karen Wei Weng Teng Chiew Yee Loh Kim Peng Tan Guillaume Carissimo Guillaume Carissimo Yi-Hao Chan Yi-Hao Chan Chek Meng Poh Chek Meng Poh Cheryl Yi-Pin Lee Cheryl Yi-Pin Lee Siew-Wai Fong Siew-Wai Fong Siew-Wai Fong Nicholas Kim-Wah Yeo Nicholas Kim-Wah Yeo Rhonda Sin-Ling Chee Rhonda Sin-Ling Chee Siti Naqiah Amrun Siti Naqiah Amrun Zi Wei Chang Zi Wei Chang Matthew Zirui Tay Matthew Zirui Tay Anthony Torres-Ruesta Anthony Torres-Ruesta Anthony Torres-Ruesta Norman Leo Fernandez Wilson How Anand Kumar Andiappan Wendy Lee Kaibo Duan Seow-Yen Tan Gabriel Yan Shirin Kalimuddin Shirin Kalimuddin David Chien Lye David Chien Lye David Chien Lye David Chien Lye Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Sean W. X. Ong Sean W. X. Ong Barnaby E. Young Barnaby E. Young Barnaby E. Young Laurent Renia Laurent Renia Lisa F. P. Ng Lisa F. P. Ng Lisa F. P. Ng Lisa F. P. Ng Bernett Lee Olaf Rötzschke Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
description	Severe SARS-CoV-2 infection can trigger uncontrolled innate and adaptive immune responses, which are commonly associated with lymphopenia and increased neutrophil counts. However, whether the immune abnormalities observed in mild to severely infected patients persist into convalescence remains unclear. Herein, comparisons were drawn between the immune responses of COVID-19 infected and convalescent adults. Strikingly, survivors of severe COVID-19 had decreased proportions of NKT and Vδ2 T cells, and increased proportions of low-density neutrophils, IgA+/CD86+/CD123+ non-classical monocytes and hyperactivated HLADR+CD38+ CD8+ T cells, and elevated levels of pro-inflammatory cytokines such as hepatocyte growth factor and vascular endothelial growth factor A, long after virus clearance. Our study suggests potential immune correlates of “long COVID-19”, and defines key cells and cytokines that delineate true and quasi-convalescent states.
format	article
author	Jackwee Lim Kia Joo Puan Liang Wei Wang Karen Wei Weng Teng Chiew Yee Loh Kim Peng Tan Guillaume Carissimo Guillaume Carissimo Yi-Hao Chan Yi-Hao Chan Chek Meng Poh Chek Meng Poh Cheryl Yi-Pin Lee Cheryl Yi-Pin Lee Siew-Wai Fong Siew-Wai Fong Siew-Wai Fong Nicholas Kim-Wah Yeo Nicholas Kim-Wah Yeo Rhonda Sin-Ling Chee Rhonda Sin-Ling Chee Siti Naqiah Amrun Siti Naqiah Amrun Zi Wei Chang Zi Wei Chang Matthew Zirui Tay Matthew Zirui Tay Anthony Torres-Ruesta Anthony Torres-Ruesta Anthony Torres-Ruesta Norman Leo Fernandez Wilson How Anand Kumar Andiappan Wendy Lee Kaibo Duan Seow-Yen Tan Gabriel Yan Shirin Kalimuddin Shirin Kalimuddin David Chien Lye David Chien Lye David Chien Lye David Chien Lye Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Sean W. X. Ong Sean W. X. Ong Barnaby E. Young Barnaby E. Young Barnaby E. Young Laurent Renia Laurent Renia Lisa F. P. Ng Lisa F. P. Ng Lisa F. P. Ng Lisa F. P. Ng Bernett Lee Olaf Rötzschke
author_facet	Jackwee Lim Kia Joo Puan Liang Wei Wang Karen Wei Weng Teng Chiew Yee Loh Kim Peng Tan Guillaume Carissimo Guillaume Carissimo Yi-Hao Chan Yi-Hao Chan Chek Meng Poh Chek Meng Poh Cheryl Yi-Pin Lee Cheryl Yi-Pin Lee Siew-Wai Fong Siew-Wai Fong Siew-Wai Fong Nicholas Kim-Wah Yeo Nicholas Kim-Wah Yeo Rhonda Sin-Ling Chee Rhonda Sin-Ling Chee Siti Naqiah Amrun Siti Naqiah Amrun Zi Wei Chang Zi Wei Chang Matthew Zirui Tay Matthew Zirui Tay Anthony Torres-Ruesta Anthony Torres-Ruesta Anthony Torres-Ruesta Norman Leo Fernandez Wilson How Anand Kumar Andiappan Wendy Lee Kaibo Duan Seow-Yen Tan Gabriel Yan Shirin Kalimuddin Shirin Kalimuddin David Chien Lye David Chien Lye David Chien Lye David Chien Lye Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Yee-Sin Leo Sean W. X. Ong Sean W. X. Ong Barnaby E. Young Barnaby E. Young Barnaby E. Young Laurent Renia Laurent Renia Lisa F. P. Ng Lisa F. P. Ng Lisa F. P. Ng Lisa F. P. Ng Bernett Lee Olaf Rötzschke
author_sort	Jackwee Lim
title	Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_short	Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_full	Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_fullStr	Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_full_unstemmed	Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals
title_sort	data-driven analysis of covid-19 reveals persistent immune abnormalities in convalescent severe individuals
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/09415a4209cb486cbf1d519aa8d7c6ff
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Data-Driven Analysis of COVID-19 Reveals Persistent Immune Abnormalities in Convalescent Severe Individuals

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