Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study

Abstract Cleft births surveillance is essential in healthcare and prevention planning. Data are needed in precision medicine to target upstream management for at-risk individuals. This study characterizes Singapore’s population-based orofacial cleft topography by ethnicity and gender, and establishe...

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Autores principales:	Mimi Yow, Aizhen Jin, George Seow Heong Yeo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/0944433604574f15a576977b90f7633b
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spelling	oai:doaj.org-article:0944433604574f15a576977b90f7633b2021-12-02T14:15:53ZEpidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study10.1038/s41598-021-87229-42045-2322https://doaj.org/article/0944433604574f15a576977b90f7633b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87229-4https://doaj.org/toc/2045-2322Abstract Cleft births surveillance is essential in healthcare and prevention planning. Data are needed in precision medicine to target upstream management for at-risk individuals. This study characterizes Singapore’s population-based orofacial cleft topography by ethnicity and gender, and establishes the cleft cohort’s infant mortality rate. Data, in the decade 2003 to 2012, were extracted by the National Birth Defects Registry. Trend testing by linear regression was at p < 0.05 significance level. Prevalence per 10,000 for population-based cleft live births was 16.72 with no significant upward trend (p = 0.317). Prevalence rates were 8.77 in the isolated cleft group, 7.04 in the non-isolated cleft group, and 0.91 in the syndromic cleft group. There was significant upward trend in infants with non-isolated clefts (p = 0.0287). There were no significant upward trends in infants with isolated clefts and syndromic clefts. Prevalence rates were sexually dimorphic and ethnic-specific: male 17.72; female 15.78; Chinese group 17.17; Malay group 16.92; Indian group 10.74; and mixed ethnic origins group 21.73. The overall infant mortality rate (IMR) was 4.8% in the cohort of 608 cleft births, which was more than double the population-based IMR of 2.1% in the same period. Infants with non-isolated and syndromic clefts accounted for 96.6% of the deaths.Mimi YowAizhen JinGeorge Seow Heong YeoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mimi Yow Aizhen Jin George Seow Heong Yeo Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
description	Abstract Cleft births surveillance is essential in healthcare and prevention planning. Data are needed in precision medicine to target upstream management for at-risk individuals. This study characterizes Singapore’s population-based orofacial cleft topography by ethnicity and gender, and establishes the cleft cohort’s infant mortality rate. Data, in the decade 2003 to 2012, were extracted by the National Birth Defects Registry. Trend testing by linear regression was at p < 0.05 significance level. Prevalence per 10,000 for population-based cleft live births was 16.72 with no significant upward trend (p = 0.317). Prevalence rates were 8.77 in the isolated cleft group, 7.04 in the non-isolated cleft group, and 0.91 in the syndromic cleft group. There was significant upward trend in infants with non-isolated clefts (p = 0.0287). There were no significant upward trends in infants with isolated clefts and syndromic clefts. Prevalence rates were sexually dimorphic and ethnic-specific: male 17.72; female 15.78; Chinese group 17.17; Malay group 16.92; Indian group 10.74; and mixed ethnic origins group 21.73. The overall infant mortality rate (IMR) was 4.8% in the cohort of 608 cleft births, which was more than double the population-based IMR of 2.1% in the same period. Infants with non-isolated and syndromic clefts accounted for 96.6% of the deaths.
format	article
author	Mimi Yow Aizhen Jin George Seow Heong Yeo
author_facet	Mimi Yow Aizhen Jin George Seow Heong Yeo
author_sort	Mimi Yow
title	Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
title_short	Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
title_full	Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
title_fullStr	Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
title_full_unstemmed	Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
title_sort	epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/0944433604574f15a576977b90f7633b
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Epidemiologic trends of infants with orofacial clefts in a multiethnic country: a retrospective population-based study

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