The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations

Acute coronary syndrome (ACS) is characterised by increased effector cells and decreased regulatory T-cells (Tregs). Statins have been shown to be clinically beneficial in ACS patients. This effect could be mediated via the induction of Tregs in ACS patients. The aim of this systemic review and meta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nilofer Sorathia, Hussein Al-Rubaye, Benham Zal
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2019
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/0945510e0ab2486b9f36c871b73b1f1d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:0945510e0ab2486b9f36c871b73b1f1d
record_format	dspace
spelling	oai:doaj.org-article:0945510e0ab2486b9f36c871b73b1f1d2021-12-04T16:01:43ZThe Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations10.15420/ecr.2019.9.21758-37641758-3756https://doaj.org/article/0945510e0ab2486b9f36c871b73b1f1d2019-07-01T00:00:00Zhttps://www.ecrjournal.com/articles/CD4-CD25-FOXP3-Regulatory-T-Cells-Acute-Coronary-Syndromehttps://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Acute coronary syndrome (ACS) is characterised by increased effector cells and decreased regulatory T-cells (Tregs). Statins have been shown to be clinically beneficial in ACS patients. This effect could be mediated via the induction of Tregs in ACS patients. The aim of this systemic review and meta-analysis was to evaluate whether statin therapy enhances the frequency of Tregs determined by CD4+CD25+FOXP3+ in this subset of patients. A comprehensive search of PubMed and Embase was performed. Studies were restricted to randomised controlled trials that quantified CD4+CD25+FOXP3+ cell frequency by flow cytometric analysis before and after statin treatment in adults diagnosed with ACS. A minimum of at least two of the conventional markers to identify Tregs was compulsory. Four randomised controlled trials studies (439 participants) were included, all with low-to-moderate risk of bias. Pooled data showed a significant increase in Treg frequency after statin therapy in ACS patients. A further meta-regression and subgroup analysis also showed a negative dose-related effect, and a statin type-related effect (rosuvastatin versus atorvastatin), respectively. The results confirmed that statins positively alter the frequency of Tregs, which may indicate a potential mechanism of their therapeutic effect. However, there was a risk of information bias due to the markers used to identify Tregs, which was not fully explored, therefore, further randomised controlled trials should utilise markers of Tregs, such as the FOXP3 locus (Treg-specific demethylated region), for identification.Nilofer SorathiaHussein Al-RubayeBenham ZalRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 14, Iss 2, Pp 123-129 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Nilofer Sorathia Hussein Al-Rubaye Benham Zal The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations
description	Acute coronary syndrome (ACS) is characterised by increased effector cells and decreased regulatory T-cells (Tregs). Statins have been shown to be clinically beneficial in ACS patients. This effect could be mediated via the induction of Tregs in ACS patients. The aim of this systemic review and meta-analysis was to evaluate whether statin therapy enhances the frequency of Tregs determined by CD4+CD25+FOXP3+ in this subset of patients. A comprehensive search of PubMed and Embase was performed. Studies were restricted to randomised controlled trials that quantified CD4+CD25+FOXP3+ cell frequency by flow cytometric analysis before and after statin treatment in adults diagnosed with ACS. A minimum of at least two of the conventional markers to identify Tregs was compulsory. Four randomised controlled trials studies (439 participants) were included, all with low-to-moderate risk of bias. Pooled data showed a significant increase in Treg frequency after statin therapy in ACS patients. A further meta-regression and subgroup analysis also showed a negative dose-related effect, and a statin type-related effect (rosuvastatin versus atorvastatin), respectively. The results confirmed that statins positively alter the frequency of Tregs, which may indicate a potential mechanism of their therapeutic effect. However, there was a risk of information bias due to the markers used to identify Tregs, which was not fully explored, therefore, further randomised controlled trials should utilise markers of Tregs, such as the FOXP3 locus (Treg-specific demethylated region), for identification.
format	article
author	Nilofer Sorathia Hussein Al-Rubaye Benham Zal
author_facet	Nilofer Sorathia Hussein Al-Rubaye Benham Zal
author_sort	Nilofer Sorathia
title	The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations
title_short	The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations
title_full	The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations
title_fullStr	The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations
title_full_unstemmed	The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations
title_sort	effect of statins on the functionality of cd4+cd25+foxp3+ regulatory t-cells in acute coronary syndrome: a systematic review and meta-analysis of randomised controlled trials in asian populations
publisher	Radcliffe Medical Media
publishDate	2019
url	https://doaj.org/article/0945510e0ab2486b9f36c871b73b1f1d
work_keys_str_mv	AT nilofersorathia theeffectofstatinsonthefunctionalityofcd4cd25foxp3regulatorytcellsinacutecoronarysyndromeasystematicreviewandmetaanalysisofrandomisedcontrolledtrialsinasianpopulations AT husseinalrubaye theeffectofstatinsonthefunctionalityofcd4cd25foxp3regulatorytcellsinacutecoronarysyndromeasystematicreviewandmetaanalysisofrandomisedcontrolledtrialsinasianpopulations AT benhamzal theeffectofstatinsonthefunctionalityofcd4cd25foxp3regulatorytcellsinacutecoronarysyndromeasystematicreviewandmetaanalysisofrandomisedcontrolledtrialsinasianpopulations AT nilofersorathia effectofstatinsonthefunctionalityofcd4cd25foxp3regulatorytcellsinacutecoronarysyndromeasystematicreviewandmetaanalysisofrandomisedcontrolledtrialsinasianpopulations AT husseinalrubaye effectofstatinsonthefunctionalityofcd4cd25foxp3regulatorytcellsinacutecoronarysyndromeasystematicreviewandmetaanalysisofrandomisedcontrolledtrialsinasianpopulations AT benhamzal effectofstatinsonthefunctionalityofcd4cd25foxp3regulatorytcellsinacutecoronarysyndromeasystematicreviewandmetaanalysisofrandomisedcontrolledtrialsinasianpopulations
_version_	1718372716741918720

The Effect of Statins on the Functionality of CD4+CD25+FOXP3+ Regulatory T-cells in Acute Coronary Syndrome: A Systematic Review and Meta-analysis of Randomised Controlled Trials in Asian Populations

Ejemplares similares