Gimap5-dependent inactivation of GSK3β is required for CD4+ T cell homeostasis and prevention of immune pathology

Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death.

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Detalles Bibliográficos
Autores principales: Andrew R. Patterson, Mehari Endale, Kristin Lampe, Halil I. Aksoylar, Aron Flagg, Jim R. Woodgett, David Hildeman, Michael B. Jordan, Harinder Singh, Zeynep Kucuk, Jack Bleesing, Kasper Hoebe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/09487aa202ff4465abb8756803164dd9
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Sumario:Loss of function GIMAP5 mutation is associated with lymphopenia, but how it mediates T cell homeostasis is unclear. Here the authors study Gimap5−/− mice and a patient with GIMAP5 deficiency to show how this GTPAse negatively regulates GSK3β activity to prevent DNA damage and cell death.